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JBC, Vol. 251, Issue 24, 7816-7820, Dec, 1976
P. Borgeat, M. Hamberg and B. Samuelsson
Addition of arachidonic acid and homo-gamma-linolenic acid to a suspension
of rabbit peritoneal neutrophils led to the synthesis of
5-L-hydroxy-6,8,11,14-eicosatetraenoic acid and
8-L-hydroxy-9,11,14-eicosatrienoic acid, respectively. Both hydroxy acids
were found to be the main metabolites of their respective unsaturated C-20
fatty acid precursor, constituting more than 50% of the total substrate
conversion. The formation of the two metabolites was not inhibted bb
indomethacin, indicating that the enzymes involved were unrelated to the
prostaglandin synthetase system. The presence in the two compounds of a
hydroxyl group alpha to a pair of conjugated cis/trans double bonds
suggested that they were formed by action of lipoxygenease(s).
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases
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