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JBC, Vol. 252, Issue 11, 3578-3581, Jun, 1977
A. Abuchowski, T. van Es, N. C. Palczuk and F. F. Davis
Methoxypolyethylene glycols of 1900 and 5000 daltons have been attached
covalently to bovine serum albumin using cyanuric chloride as the coupling
agent. When sufficient polymer is attached, the modified bovine serum
albumin appears to lose its immunogenicity in the rabbit and, on
intramuscular or intravenous injection, elicits antibodies neither to
itself nor to native bovine serum albumin. It does not react with
antibodies raised against native bovine serum albumin. Bovine serum albumin
to which methoxypolyethylene glycol has been attached exhibits a blood
circulating life in the rabbit rather similar to native bovine serum
albumin, except that it is not removed from circulation by the eventual
development of antibodies. Modified bovine serum albumins which had been
iodinated with 125I, or prepared with [14C]cyanuric chloride, were injected
intravenously in rabbits. Both labels appeared almost quantitatively in the
urine after 30 days. The modified bovine serum albumins showed substantial
changes in properties, such as solubility, electrophoretic mobility in
acrylamide gel, ion exchange chromatography, and sedimentation, as compared
with the unmodified protein.
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
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