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JBC, Vol. 252, Issue 21, 7818-7825, Nov, 1977

Biochemical and immunological properties of gag genecoded structural proteins of endogenous tyep C RNA tumor viruses of diverse mammalian species

J. R. Stephenson, R. K. Reynolds, S. G. Devare and F. H. Reynolds

The major nonglycosylated structure proteins of mammalian type C RNA tumor viruses are synthesized in the form of a high molecular weight precursor coded for by a viral gene disignated "gag". Previous genetic analysis of a prototype virus isolated of mouse origin has led to a determination of the internal arragnement of the regions within the gag gene coding for individual structural proteins. In the present study, the biochemical properties of structural proteins of type C virus isolates of additional mammalian species were analyzed. The results obtained indicate that the biochemical properties of immunologically cross-reactive proteins have been highly conserved throughout the evolution of this group of viruses. Moreover, these findings provide a means of mapping the gag genes of a broad range of mammalian type C viruses. In view of the results obtained, a new nomenclature system for type C viral gag gene-coded translational products is proposed.
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This article has been cited by other articles:

				J. R. Stephenson, W. J. M. Van de Ven, A. S. Khan, and F. H. Reynolds Jr. Mammalian RNA Type-C Transforming Viruses: Characterization of Virus-coded Polyproteins Containing Phosphorylated Components with Possible Transforming Functions Cold Spring Harb Symp Quant Biol, January 1, 1980; 44(0): 865 - 874. [Abstract] [PDF]