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JBC, Vol. 254, Issue 8, 2643-2646, Apr, 1979
P. Borgeat and B. Samuelsson
A new metabolite of arachidonic acid,
5-D-(S),12-D-(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid, was found upon
incubation of the fatty acid with a suspension of rabbit peritoneal
polymorphonuclear leukocytes collected 4 h after injection of glycogen into
the peritoneal cavity. The yield of the dihydroxy acid was 0.5 to 2%. The
compound possesses three conjugated double bonds and was found to be
stereochemically pure at C-5 and C-12. Incubation of the cells with
8,11,14-eicosatrienoic acid did not lead to the formation of the analogous
triunsaturated dihydroxy acid.
Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid
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