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J. Biol. Chem., Vol. 255, Issue 11, 4976-4979, Jun, 1980

Decatenation of kinetoplast DNA by topoisomerases

JC Marini, KG Miller and PT Englund

Kinetoplast DNA is the mitochondrial DNA of trypanosomatids such as Crithidia fasciculata. This DNA is in the form of networks containing thousands of DNA circles which are apparently catenated (interlocked). Some topoisomerases, such as T4 phage topoisomerase and DNA gyrase, catalyze a decatenation of the networks to form individual covalently closed circles.
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