J. Biol. Chem., Vol. 255, Issue 11, 4984-4987, Jun, 1980
Dissimilar modes of expression of beta- and gamma-actin in normal and leukemic human T lymphocytes
J Leavitt, A Leavitt and AM Attallah
Actin polypeptides are the most abundant protein components of replicating
normal human T lymphocytes, comprising 16% of the total cellular protein.
Unlike other replicating cell types which synthesize equal proportions of
beta- and gamma-actin polypeptides, T cells synthesize beta-actin as the
predominant species. By contrast, leukemic T cells (the Molt-4 cell line)
synthesize nearly equal proportions of beta- and gamma-actin. In addition,
novel forms of beta-actin in normal T cells and of beta- and gamma-actin in
Molt-4 cells appear to be present, perhaps resulting from a
post-translational modification process. Otherwise, both divergent T cell
types express a relatively common spectrum of polypeptide species, thereby
suggesting that regulation of actin biosynthesis may be involved in the
neoplastic transformation process.
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