HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mellon-Nussbaum, S. Articles by Hochberg, R. B. Search for Related Content PubMed PubMed Citation Articles by Mellon-Nussbaum, S. Articles by Hochberg, R. B. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 255, Issue 12, 5566-5572, 06, 1980

Biosynthesis of lipoidal derivatives of pregnenolone and dehydroisoandrosterone by the adrenal

S Mellon-Nussbaum and RB Hochberg

The incubation of pregnenolone or dehydroisoandrosterone with bovine or rat adrenal homogenates leads to the formation of nonpolar metabolites of these steroids. The enzymatically prepared compounds have properties that are similar to the endogenous lipoidal derivatives of pregnenolone found in bovine adrenals (Hochberg, R. B., Bandy, L., Ponticorvo, L., and Lieberman, S. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 941-945) in that they are much less polar than the parent steroid and yield the parent steroid as a product of treatment with alkali. The lipoidal derivatives of both dehydroisoandrosterone and pregnenolone proved to be chromatographically heterogeneous. 17 alpha-Hydroxypregnenolone, 17 alpha-hydroxyprogesterone, progesterone, and testosterone were not converted into lipoidal derivatives when incubated with the bovine adrenal homogenate.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. Raber, S. F. Akana, S. Bhatnagar, M. F. Dallman, D. Wong, and L. Mucke Hypothalamic-Pituitary-Adrenal Dysfunction in Apoe-/- Mice: Possible Role in Behavioral and Metabolic Alterations J. Neurosci., March 1, 2000; 20(5): 2064 - 2071. [Abstract] [Full Text] [PDF]

				A. G. Mensah-Nyagan, J.-L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System Pharmacol. Rev., March 1, 1999; 51(1): 63 - 82. [Abstract] [Full Text] [PDF]

				R. B. Hochberg Biological Esterification of Steroids Endocr. Rev., June 1, 1998; 19(3): 331 - 348. [Abstract] [Full Text]

				J. Raber, R. D. O'Shea, F. E. Bloom, and I. L. Campbell Modulation of Hypothalamic-Pituitary-Adrenal Function by Transgenic Expression of Interleukin-6 in the CNS of Mice J. Neurosci., December 15, 1997; 17(24): 9473 - 9480. [Abstract] [Full Text] [PDF]