J. Biol. Chem., Vol. 255, Issue 12, 5649-5654, 06, 1980
Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. In vivo synthesis of folates
B Shane
Corynebacterium sp. synthesizes pteroylpolyglutamates which are excreted
into its growth medium. The major intracellular folates were identified as
10-formyltetrahydro-, 5-formyltetrahydro-, tetrahydro-, and
10-formylpteroyltetraglutamates. The major folates in the medium were
identified as 10-formylpteroyltri- and tetraglutamates. p- Aminobenzoic was
metabolized to these compounds without any appreciable buildup of
pteroylmono- or diglutamate derivatives. The rate-limiting steps in the
elongation of the glutamate chain of folate derivatives appear to be at the
level of formation of a pteroate derivative and at the
pteroyltetraglutamate level.
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