J. Biol. Chem., Vol. 255, Issue 14, 6569-6574, 07, 1980
A Ser162/Gly162 polymorphism in Japanese quail ovomucoid
WC Bogard Jr, I Kato and M Laskowski Jr
Japanese quail ovomucoid exists in two polymorphic forms. One has serine,
the other glycine at position 162. The tryptic peptide corresponding to
positions 160 to 164 was purified from ovomucoids isolated from egg whites
of eggs laid by 11 different hens and subjected to amino acid analysis. The
quantitative distribution of serine and glycine in this pentapeptide is
consistent with the interpretation that the ovomucoid gene exists in two
codominant allelic forms at one locus. Even though the gene product is
apparently expressed only in the female, these results indicate that the
ovomucoid structural gene is transmitted as a simple Mendelian character
which is neither sex-linked nor shows dominance. Intact third domains
(positions 131 to 186) isolated from the two allelic forms of ovomucoid
interact with bovine beta-trypsin in a similar but not identical manner;
the complex with the glycine form dissociates more rapidly. Evidence is
presented which suggests that glycine is the ancestral residue at position
162; yet, the serine form is the more frequent phenotype.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
