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J. Biol. Chem., Vol. 255, Issue 14, 6653-6661, 07, 1980
K Atkinson, S Fogel and SA Henry
Phospholipid biosynthesis in a mutant of Saccharomyces cerevisiae (cho1)
which lacks phosphatidylserine (Atkinson, K. D., Jensen, B., Storm, E.,
Kolat, A. I., Henry, S. A. & Fogel, S. (1980) J. Bacteriol. 141,
558-564) has been examined. The ability of cells of this strain to
synthesize phosphatidylserine in vitro in a cell-free system is reduced at
least 10-fold, whereas other phospholipid-synthesizing activities are
present at normal or slightly elevated levels. While all phospholipid
biosynthetic activities, except phosphatidylserine synthesis, can be
demonstrated in vitro in the cho1 mutant, the entire pattern of
phospholipid synthesis, accumulation, and turnover in vivo is distorted.
Phosphatidylinositol synthesis is elevated, as is phosphatidylcholine
synthesis. In addition, the turnover of phosphatidylcholine is more rapid
in the cho1 mutant. The cho1 mutant appears to use almost exclusively the
alternative pathway described by Kennedy and Weiss (1956) J. Biol. Chem.
222, 193-214) for the production of phosphatidylethanolamine and
phosphatidylcholine, bypassing phosphatidylserine as an intermediate.
Yeast mutant defective in phosphatidylserine synthesis
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