JBC Transcription and Nuclear Factor Monoclonals

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J. Biol. Chem., Vol. 255, Issue 18, 8405-8407, Sep, 1980

Structure of an amniotic fluid component, 7-(4,5-cis-dihydroxy-1- cyclopenten-3-ylaminomethyl)-7-deazaguanine (queuine), a substrate for tRNA: guanine transglycosylase

PF Crain, SK Sethi, JR Katze and JA McCloskey

A compound present in bovine amniotic fluid, and which is a substrate for tRNA:guanine transglycosylase, has been structurally characterized as queuine, a hypermodified base which occurs in transfer RNA. The structure assignment is based on mass spectrometry, proton nuclear magnetic resonance, and ultraviolet absorbance data.
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Katze JR, B Basile, and J. McCloskey
Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature
Science, April 2, 1982; 216(4541): 55 - 56.
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