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J. Biol. Chem., Vol. 255, Issue 2, 342-344, 01, 1980

Independent actions of gonadotropin releasing hormone upon cyclic GMP production and luteinizing hormone release

Z Naor and KJ Catt

Gonadotropin releasing hormone (GnRH) and its potent analog [D- Ser(tBu)6]des-Gly10-GnRH N-ethylamide elevate pituitary cyclic GMP levels while stimulating gonadotropin release in cultured pituitary cells. Addition of mycophenolic acid to pituitary cell cultures decreased basal and GnRH-induced cGMP production to undetectable levels, but did not reduce basal or GnRH-stimulated luteinizing hormone (LH) release. Elevation of endogenous cGMP levels by sodium nitroprusside, or addition of cGMP or its potent derivatives, was also without effect on basal or GnRH-stimulated LH release. These findings demonstrate that the elevation of intracellular cGMP during GnRH action does not mediate the release of LH by pituitary cells.
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