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J. Biol. Chem., Vol. 255, Issue 2, 518-521, 01, 1980

Enzymatic synthesis of 15-hydroperoxythromboxane A2 and 12-hydroperoxy- 5,8,10-heptadecatrienoic acid

S Hammarstrom

Partially purified thromboxane synthase from human platelets converted prostaglandin G2 to two products. These were transformed to 12-hydroxy- 5,8,10-heptadecatrienoic acid and thromboxane B2 by stannous chloride reduction and to 12-keto-5,8,10-heptadecatrienoic acid and 15- ketothromboxane B2 by lead tetraacetate dehydration. Trapping with methanol after short incubations of substrate with enzyme and reduction by stannous chloride yielded 11-O-methylthromboxane B2. Based on these results, the enzymatically formed products were identified as 12- hydroperoxy-5,8,10-heptadecatrienoic acid and 15-hydroperoxythromboxane A2.
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