HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hartshorne, R. P. Articles by Catterall, W. A. Search for Related Content PubMed PubMed Citation Articles by Hartshorne, R. P. Articles by Catterall, W. A. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 255, Issue 22, 10572-10575, 11, 1980

Size characteristics of the solubilized saxitoxin receptor of the voltage-sensitive sodium channel from rat brain

RP Hartshorne, J Coppersmith and WA Catterall

The saxitoxin receptor of the voltage-sensitive sodium channel from rat brain was solubilized with Triton X-100 and stabilized with phosphatidylcholine. The size characteristics of the detergent . phospholipid . receptor complex were studied by gel filtration and sucrose gradient sedimentation in H2O and D2O. The complex has Stokes radius = 80 A, S20,W = 12 S, v = 0.82 ml/ g, and Mr = 601,000 +/- 48,000. Assuming v = 0.73 ml/g for the saxitoxin receptor protein, the mass of the complex consists of 47.4% detergent and phosphatidylcholine and 52.6% saxitoxin receptor protein with Mr = 316,000 +/- 63,000.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?