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J. Biol. Chem., Vol. 255, Issue 4, 1239-1241, 02, 1980
HT Haigler, FR Maxfield, MC Willingham and I Pastan
The binding and internalization of 125I-epidermal growth factor (125I- EGF)
was studied in cultures of BALB 3T3 cells using a novel method that
involved removal of cell-surface hormone by treatment with acetic acid
under conditions that did not remove internalized hormone. In control
cultures, 125I-EGF initially bound to its receptor on the plasma membrane
and then was rapidly internalized. After 30 min, only 15% of the cell-bound
hormone remained on the surface. In contrast, cultures treated with
dansylcadaverine retained 82% of the cell-bound hormone on the cell
surface. We propose that dansylcadaverine inhibits EGF internalization by
preventing it from clustering in clathrin-coated pits.
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells
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|
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|
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|
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|
|
|
|
|
|
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|
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|
|
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|
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|
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|
|
|
|
 |
|
 A Wells, J. Welsh, C. Lazar, H. Wiley, G. Gill, and M. Rosenfeld Ligand-induced transformation by a noninternalizing epidermal growth factor receptor Science, February 23, 1990; 247(4945): 962 - 964. [Abstract] [PDF]
|
|
|
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|
|
|
|
|
|
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