HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nagel, W. O. Articles by Sauer, L. A. Search for Related Content PubMed PubMed Citation Articles by Nagel, W. O. Articles by Sauer, L. A. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 255, Issue 9, 3849-3854, 05, 1980

Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues

WO Nagel, RT Dauchy and LA Sauer

The activities of the mitochondrial NAD(P)+- and NADP+-dependent malic enzymes were measured in 11 tissues of the male Sprague-Dawley rat. The NAD(P)+-dependent malic enzyme was present in small intestinal mucosa, spleen, thymus, lung, and testis. Each of these tissues contain cells that are undergoing active rates of renewal. The NADP+-dependent malic enzyme was not confined to tissues undergoing cell renewal, and was present in mitochondria from brain, skeletal, and heart muscle, kidney, and lung and testis. Both enzymes were absent or at a low activity in normal and regenerating liver. The results support, and extent to nonneoplastic tissues, our proposal that cells which show active and sustained rates of renewal contain the NAD(P)+-dependent malic enzyme and have a unique intramitochondrial pathway for malate oxidation (Sauer, L.A., Dauchy, R.T., Nagel, W.O., and Morris, H.P. (1980) J. Biol. Chem. 255, 3844-3848).
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. Stoll, D. G. Burrin, J. Henry, H. Yu, F. Jahoor, and P. J. Reeds Substrate oxidation by the portal drained viscera of fed piglets Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E168 - E175. [Abstract] [Full Text] [PDF]

				V. Goossens, J. Grooten, and W. Fiers The Oxidative Metabolism of Glutamine J. Biol. Chem., January 5, 1996; 271(1): 192 - 196. [Abstract] [Full Text] [PDF]

				J. C. Chatham, J. R. Forder, J. D. Glickson, and E. M. Chance Calculation of Absolute Metabolic Flux and the Elucidation of the Pathways of Glutamate Labeling in Perfused Rat Heart by [IMAGE]C NMR Spectroscopy and Nonlinear Least Squares Analysis J. Biol. Chem., April 7, 1995; 270(14): 7999 - 8008. [Abstract] [Full Text] [PDF]