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J. Biol. Chem., Vol. 256, Issue 17, 8882-8884, 09, 1981

Growth hormone stimulates drug-induced porphyrin formation in liver cells maintained in a serum-free medium

S Sassa, DW Golde and CH Li

Human growth hormone and a few other related polypeptide hormones enhanced porphyrin formation induced by 2-allyl-2-isopropylacetamide in chick embryo liver cells maintained in a serum-free medium. The stimulatory effect of human growth hormone on drug-induced porphyrin formation was significant at 10 ng/ml and increased in a dose-dependent manner. Human growth hormone did not stimulate porphyrin formation in otherwise untreated cultures. These findings thus demonstrate a potentiating effect of growth hormones on hepatic porphyrin formation.
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