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J. Biol. Chem., Vol. 256, Issue 19, 9924-9931, 10, 1981
EH Oliw, JA Lawson, AR Brash and JA Oates
[1-14C]Eicosatetraenoic (arachidonic) acid was incubated with a low speed
(17,000 X g) rabbit renal cortical supernatant or with a cortical
microsomal suspension fortified with NADPH for 15 min at 37 degrees C. The
products which were less polar than prostaglandins on reversed phase high
performance liquid chromatography were identified by gas
chromatography-mass spectrometry. Both the fortified microsomes and the low
speed supernatant formed significant amounts of two novel metabolites,
11,12-dihydroxy-5,8,14-eicosatrienoic acid and 14,15-
dihydroxy-5,8,11-eicosatrienoic acid. Other identified products were 19-
and 20-hydroxyeicosatetraenoic acid, 19-oxoeicosatetraenoic acid, and in
the low speed supernatant, eicosatetraen-1,20-dioic acid. The metabolites
were not formed in significant amounts by high speed cortical supernatant
or by nonfortified cortical microsomes. Carbon monoxide inhibited formation
of these compounds, indicating that they may be formed by the cytochrome
P-450-linked renal monooxygenase systems.
Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids
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