HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Boudier, C. Articles by Bieth, J. G. Search for Related Content PubMed PubMed Citation Articles by Boudier, C. Articles by Bieth, J. G. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 256, Issue 20, 10256-10258, Oct, 1981

Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G

C Boudier, C Holle and JG Bieth

Human leukocyte cathespin G strongly stimulates the rate of solubilization of human lung elastin by human leukocyte elastase. For instance, the elastolytic activity of an equimolar mixture of elastase and cathepsin G is more than 5 times higher than that of elastase alone. Optimal stimulation occurs only if cathepsin G and elastase act simultaneously on elastin. Potentiation of leukocyte elastase digestion of lung elastin may also be brought about by bovine alpha-chymotrypsin. This enzyme is about half as efficient as cathepsin G. Stimulation of leukocyte elastase activity by cathepsin G is about 3 times less pronounced with bovine ligamentum nuchae elastin than with human lung elastin. On the other hand, the elastolytic activity of porcine pancreatic elastase is only enhanced by 20 to 30% by cathepsin. Therefore, maximal potentiation of elastolysis occurs with the lung elastin/leukocyte elastase system. The pathologic relevance of these findings is discussed.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Q.-L. Ying and S. R. Simon Elastolysis by Proteinase 3 and its Inhibition by alpha 1-Proteinase Inhibitor . A Mechanism for the Incomplete Inhibition of Ongoing Elastolysis Am. J. Respir. Cell Mol. Biol., March 1, 2002; 26(3): 356 - 361. [Abstract] [Full Text] [PDF]

				J. Duranton, C. Boudier, D. Belorgey, P. Mellet, and J. G. Bieth DNA Strongly Impairs the Inhibition of Cathepsin G by alpha 1-Antichymotrypsin and alpha 1-Proteinase Inhibitor J. Biol. Chem., February 11, 2000; 275(6): 3787 - 3792. [Abstract] [Full Text] [PDF]