| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 256, Issue 4, 1522-1524, Feb, 1981
ML McKean, JB Smith and MJ Silver
Significant increases in lysophosphatidylcholine from a basal level of 4.2
+/- 0.36 nmol/mg of platelet protein to 6.4 +/- 0.46 nmol/mg of protein
occur within 20 s after the addition of thrombin (5 units/ml) to washed
human platelets. The increases are essentially complete by 1 min, at which
time levels of 8.5 +/- 0.53 nmol of lysophosphatidylcholine/mg of platelet
protein are reached. Decreases in phosphatidylcholine and also
phosphatidylethanolamine occur within 20 s after stimulation of platelets
by thrombin. These changes were detected by quantitative measurements of
endogenous phospholipid phosphorus after extraction and thin layer
chromatography of the platelet lipids. The concomitant increases in
lysophosphatidylcholine and decreases in phosphatidylcholine, as well as
the decreases in phosphatidylethanolamine, can only be explained by the
stimulation of phospholipase A2 activity in platelets by thrombin.
Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Hsiao, K. H. Lin, Y. Chang, T. L. Chen, N. H. Tzu, D. S. Chou, and J. R. Sheu Protective Mechanisms of Inosine in Platelet Activation and Cerebral Ischemic Damage Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1998 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, C. G. Radu, L. V. Yang, L. A. Bentolila, M. Riedinger, and O. N. Witte Lysophosphatidylcholine-induced Surface Redistribution Regulates Signaling of the Murine G Protein-coupled Receptor G2A Mol. Biol. Cell, May 1, 2005; 16(5): 2234 - 2247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Sheu, G. Hsiao, M. Y. Shen, Y. Wang, K. H. Lin, C. H. Lin, and D. S. Chou Inhibitory Mechanisms of Metallothionein on Platelet Aggregation in In Vitro and Platelet Plug Formation in In Vivo Experiments Experimental Biology and Medicine, December 1, 2003; 228(11): 1321 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Kramer, E. F. Roberts, S. L. Um, A. G. Borsch-Haubold, S. P. Watson, M. J. Fisher, and J. A. Jakubowski p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets. EVIDENCE THAT PROLINE-DIRECTED PHOSPHORYLATION IS NOT REQUIRED FOR MOBILIZATION OF ARACHIDONIC ACID BY cPLA2 J. Biol. Chem., November 1, 1996; 271(44): 27723 - 27729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science, October 23, 1992; 258(5082): 607 - 614. [Abstract] [PDF]
|
|
|
|
|
|
P. Majerus, T. Connolly, H Deckmyn, T. Ross, T. Bross, H Ishii, V. Bansal, and D. Wilson The metabolism of phosphoinositide-derived messenger molecules Science, December 19, 1986; 234(4783): 1519 - 1526. [Abstract] [PDF]
|
|
|
|
|
|
D Bar-Sagi and J. Feramisco Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science, September 5, 1986; 233(4768): 1061 - 1068. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
