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J. Biol. Chem., Vol. 256, Issue 4, 1608-1610, Feb, 1981

Manganese effects on gluconeogenesis

R Rognstad

Manganese (Mn2+) does not significantly increase gluconeogenesis from lactate (10 mM) plus pyruvate (1 mM) in hepatocytes from fasted rats. In hepatocytes not treated with Mn2+, glucagon (1 microM) and epinephrine (10 microM) at these optimal concentrations both stimulate gluconeogenesis from lactate/pyruvate (10:1), but the hormonal effects are not additive. In the presence of Mn2+ the hormonal effects are slightly larger, and the effects of glucagon (1 microM) and epinephrine (10 microM) become nearly completely additive. Mn2+ increases the specific activity of glucose formed from lactate plus NaH14CO3 by nearly 20%. The increase may be attributed to an increased exchange reaction of either pyruvate carboxylase or phosphoenolypyruvate carboxykinase, suggesting that one of these may be markedly stimulated by Mn2+, the increased exchange reaction possibly signifying an approach toward "near equilibrium" status.
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L. R. Legleiter, J. W. Spears, and K. E. Lloyd
Influence of dietary manganese on performance, lipid metabolism, and carcass composition of growing and finishing steers
J Anim Sci, October 1, 2005; 83(10): 2434 - 2439.
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