| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 259, Issue 10, 6228-6234, 05, 1984
RA Kahn and AG Gilman
A factor (ARF) that is required for the cholera toxin-dependent ADP-
ribosylation of the stimulatory, GTP-binding regulatory component (Gs) of
adenylate cyclase has been purified about 2000-fold from cholate extracts
of rabbit liver membranes. ARF is an intrinsic membrane protein with Mr =
21,000. The final product can be resolved into two polypeptides with very
similar molecular weights; each of these has ARF activity. The
ADP-ribosylation of Gs can now be studied with defined components. GTP and
ARF are both necessary cofactors. The data imply that the substrates for
the activated toxin are NAD and a GTP X Gs X ARF complex, and the reaction
proceeds in a lipid environment. The apparent ability of ARF to bind to the
alpha subunit of Gs suggests that it may play another, unknown role in the
regulation of adenylate cyclase activity.
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Nielsen, A. Y. Cheung, and T. Ueda The Regulatory RAB and ARF GTPases for Vesicular Trafficking Plant Physiology, August 1, 2008; 147(4): 1516 - 1526. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, C. Taya, H. Shitara, H. Yonekawa, et al. Crucial Role of the Small GTPase ARF6 in Hepatic Cord Formation during Liver Development. Mol. Cell. Biol., August 1, 2006; 26(16): 6149 - 6156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Nie and P. A. Randazzo Arf GAPs and membrane traffic. J. Cell Sci., April 1, 2006; 119(Pt 7): 1203 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Kahn, J. Cherfils, M. Elias, R. C. Lovering, S. Munro, and A. Schurmann Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins J. Cell Biol., February 27, 2006; 172(5): 645 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Jiang and S. Ramachandran Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes Physiol Genomics, February 23, 2006; 24(3): 235 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Volpicelli-Daley, Y. Li, C.-J. Zhang, and R. A. Kahn Isoform-selective Effects of the Depletion of ADP-Ribosylation Factors 1-5 on Membrane Traffic Mol. Biol. Cell, October 1, 2005; 16(10): 4495 - 4508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Gebbie, J. E. Burn, C. H. Hocart, and R. E. Williamson Genes encoding ADP-ribosylation factors in Arabidopsis thaliana L. Heyn.; genome analysis and antisense suppression J. Exp. Bot., April 1, 2005; 56(414): 1079 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Price, C. Panethymitaki, D. Goulding, and D. F. Smith Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes J. Cell Sci., February 15, 2005; 118(4): 831 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vichi, D. M. Payne, G. Pacheco-Rodriguez, J. Moss, and M. Vaughan E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1) PNAS, February 8, 2005; 102(6): 1945 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. LI, W. G. KELLY, J. M. LOGSDON JR, A. M. SCHURKO, B. D. HARFE, K. L. HILL-HARFE, and R. A. KAHN Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans FASEB J, December 1, 2004; 18(15): 1834 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Colicelli Human RAS Superfamily Proteins and Related GTPases Sci. Signal., September 14, 2004; 2004(250): re13 - re13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zakrzewska, M. Perron, A. Laroche, and D. Pallotta A Role for GEA1 and GEA2 in the Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae Genetics, November 1, 2003; 165(3): 985 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Nie, K. T. Stanley, S. Stauffer, K. M. Jacques, D. S. Hirsch, J. Takei, and P. A. Randazzo AGAP1, an Endosome-associated, Phosphoinositide-dependent ADP-ribosylation Factor GTPase-activating Protein That Affects Actin Cytoskeleton J. Biol. Chem., December 6, 2002; 277(50): 48965 - 48975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lu, H. Horstmann, C. Ng, and W. Hong Regulation of Golgi structure and function by ARF-like protein 1 (Arl1) J. Cell Sci., March 14, 2002; 114(24): 4543 - 4555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takai, T. Sasaki, and T. Matozaki Small GTP-Binding Proteins Physiol Rev, January 1, 2001; 81(1): 153 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yahara, T. Ueda, K. Sato, and A. Nakano Multiple Roles of Arf1 GTPase in the Yeast Exocytic and Endocytic Pathways Mol. Biol. Cell, January 1, 2001; 12(1): 221 - 238. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. McElver, D. Patton, M. Rumbaugh, C.-m. Liu, L. J. Yang, and D. Meinke The TITAN5 Gene of Arabidopsis Encodes a Protein Related to the ADP Ribosylation Factor Family of GTP Binding Proteins PLANT CELL, August 1, 2000; 12(8): 1379 - 1392. [Abstract] [Full Text]
|
|
|
|
|
|
X. Zhu, A. L. Boman, J. Kuai, W. Cieplak, and R. A. Kahn Effectors Increase the Affinity of ADP-ribosylation Factor for GTP to Increase Binding J. Biol. Chem., April 28, 2000; 275(18): 13465 - 13475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gu and J. Gruenberg ARF1 Regulates pH-dependent COP Functions in the Early Endocytic Pathway J. Biol. Chem., March 10, 2000; 275(11): 8154 - 8160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Togawa, N. Morinaga, M. Ogasawara, J. Moss, and M. Vaughan Purification and Cloning of a Brefeldin A-inhibited Guanine Nucleotide-exchange Protein for ADP-ribosylation Factors J. Biol. Chem., April 30, 1999; 274(18): 12308 - 12315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Huang, L.-M. Buu, W.-L. Yu, and F.-J. S. Lee Characterization of a Novel ADP-ribosylation Factor-like Protein (yARL3) in Saccharomyces cerevisiae J. Biol. Chem., February 5, 1999; 274(6): 3819 - 3827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Stevens, J. Moss, M. Vaughan, M. Pizza, and R. Rappuoli Effects of Site-Directed Mutagenesis of Escherichia coli Heat-Labile Enterotoxin on ADP-Ribosyltransferase Activity and Interaction with ADP-Ribosylation Factors Infect. Immun., January 1, 1999; 67(1): 259 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rattan, Y.-P. Fan, and S. Chakder Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX Am J Physiol Gastrointest Liver Physiol, January 1, 1999; 276(1): G138 - G145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Franco, J. Boretto, S. Robineau, S. Monier, B. Goud, P. Chardin, and P. Chavrier ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function PNAS, August 18, 1998; 95(17): 9926 - 9931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-j. Zhang, M. M. Cavenagh, and R. A. Kahn A Family of Arf Effectors Defined as Suppressors of the Loss of Arf Function in the Yeast Saccharomyces cerevisiae J. Biol. Chem., July 31, 1998; 273(31): 19792 - 19796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-X. Hong, F.-J. S. Lee, W. A. Patton, C. Y. Lin, J. Moss, and M. Vaughan Phospholipid- and GTP-dependent Activation of Cholera Toxin and Phospholipase D by Human ADP-ribosylation Factor-like Protein 1 (HARL1) J. Biol. Chem., June 19, 1998; 273(25): 15872 - 15876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lopez, R. S. Arnold, and J. D. Lambeth Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2). ADP-RIBOSYLATION FACTOR REGULATES hPLD2 J. Biol. Chem., May 22, 1998; 273(21): 12846 - 12852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sata, J. G. Donaldson, J. Moss, and M. Vaughan Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors PNAS, April 14, 1998; 95(8): 4204 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Gaynor, C.-Y. Chen, S. D. Emr, and T. R. Graham ARF Is Required for Maintenance of Yeast Golgi and Endosome Structure and Function Mol. Biol. Cell, March 1, 1998; 9(3): 653 - 670. [Abstract] [Full Text]
|
|
|
|
|
|
C Vasudevan, W Han, Y Tan, Y Nie, D Li, K Shome, S. Watkins, E. Levitan, and G Romero The distribution and translocation of the G protein ADP-ribosylation factor 1 in live cells is determined by its GTPase activity J. Cell Sci., January 5, 1998; 111(9): 1277 - 1285. [Abstract] [PDF]
|
|
|
|
|
|
A. Abousalham, C. Liossis, L. O'Brien, and D. N. Brindley Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA J. Biol. Chem., January 10, 1997; 272(2): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Morinaga, S.-C. Tsai, J. Moss, and M. Vaughan Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain PNAS, November 12, 1996; 93(23): 12856 - 12860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ding, N. Vitale, S.-C. Tsai, R. Adamik, J. Moss, and M. Vaughan Characterization of a GTPase-activating Protein That Stimulates GTP Hydrolysis by Both ADP-ribosylation Factor (ARF) and ARF-like Proteins. COMPARISON TO THE ARD1 GAP DOMAIN J. Biol. Chem., September 27, 1996; 271(39): 24005 - 24009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Cavenagh, J. A. Whitney, K. Carroll, C.-j. Zhang, A. L. Boman, A. G. Rosenwald, I. Mellman, and R. A. Kahn Intracellular Distribution of Arf Proteins in Mammalian Cells. Arf6 IS UNIQUELY LOCALIZED TO THE PLASMA MEMBRANE J. Biol. Chem., September 6, 1996; 271(36): 21767 - 21774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-G. Chen and D. Shields ADP-ribosylation Factor-1 Stimulates Formation of Nascent Secretory Vesicles from the trans-Golgi Network of Endocrine Cells J. Biol. Chem., March 8, 1996; 271(10): 5297 - 5300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Singer, H. A. Brown, X. Jiang, and P. C. Sternweis Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity J. Biol. Chem., February 23, 1996; 271(8): 4504 - 4510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lowe, S. Wong, and W Hong The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex J. Cell Sci., January 1, 1996; 109(1): 209 - 220. [Abstract] [PDF]
|
|
|
|
|
|
H. A. Brown, S. Gutowski, R. A. Kahn, and P. C. Sternweis Partial Purification and Characterization of Arf-sensitive Phospholipase D from Porcine Brain J. Biol. Chem., June 23, 1995; 270(25): 14935 - 14943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Randazzo, T. Terui, S. Sturch, H. M. Fales, A. G. Ferrige, and R. A. Kahn The Myristoylated Amino Terminus of ADP-ribosylation Factor 1 Is a Phospholipid- and GTP-sensitive Switch J. Biol. Chem., June 16, 1995; 270(24): 14809 - 14815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Steinberg, H. Zhang, E. Pak, G. Pagnotta, and P. A. Boyden Characteristics of the ß-Adrenergic Receptor Complex in the Epicardial Border Zone of the 5-Day Infarcted Canine Heart Circulation, June 1, 1995; 91(11): 2824 - 2833. [Abstract] [Full Text]
|
|
|
|
|
|
J. Moss and M. Vaughan Structure and Function of ARF Proteins: Activators of Cholera Toxin and Critical Components of Intracellular Vesicular Transport Processes J. Biol. Chem., May 26, 1995; 270(21): 12327 - 12330. [Full Text] [PDF]
|
|
|
|
|
|
A. R. Siddiqi, J. L. Smith, A. H. Ross, R.-G. Qiu, M. Symons, and J. H. Exton Regulation of Phospholipase D in HL60 Cells J. Biol. Chem., April 14, 1995; 270(15): 8466 - 8473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Makler, E. Cukierman, M. Rotman, A. Admon, and D. Cassel ADP-ribosylation Factor-directed GTPase-activating Protein J. Biol. Chem., March 10, 1995; 270(10): 5232 - 5237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Luján, A. Marotta, M. R. Mowatt, N. Sciaky, J. Lippincott-Schwartz, and T. E. Nash Developmental Induction of Golgi Structure and Function in the Primitive Eukaryote Giardia lamblia J. Biol. Chem., March 3, 1995; 270(9): 4612 - 4618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Franco, P. Chardin, M. Chabre, and S. Paris Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg[IMAGE] Levels J. Biol. Chem., January 20, 1995; 270(3): 1337 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-F. Zhang, W. A. Patton, F.-J. S. Lee, M. Liyanage, J.-S. Han, S. G. Rhee, J. Moss, and M. Vaughan Different ARF Domains Are Required for the Activation of Cholera Toxin and Phospholipase D J. Biol. Chem., January 6, 1995; 270(1): 21 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kahn, J. Clark, C. Rulka, T. Stearns, C.-j. Zhang, P. A. Randazzo, T. Terui, and M. Cavenagh Mutational Analysis of Saccharomyces cerevisiae ARF1 J. Biol. Chem., January 6, 1995; 270(1): 143 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Cockcroft, G. Thomas, A Fensome, B Geny, E Cunningham, I Gout, I Hiles, N. Totty, O Truong, and J. Hsuan Phospholipase D: a downstream effector of ARF in granulocytes Science, January 28, 1994; 263(5146): 523 - 526. [Abstract] [PDF]
|
|
|
|
|
|
J. Donaldson, R. Kahn, J Lippincott-Schwartz, and R. Klausner Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein Science, November 22, 1991; 254(5035): 1197 - 1199. [Abstract] [PDF]
|
|
|
|
|
|
X.-L. Zheng, S. Matsubara, C. Diao, M. D. Hollenberg, and N. C. W. Wong Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1 J. Biol. Chem., October 6, 2000; 275(41): 31747 - 31754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhu and R. A. Kahn The Escherichia coli Heat Labile Toxin Binds to Golgi Membranes and Alters Golgi and Cell Morphologies Using ADP-ribosylation Factor-dependent Processes J. Biol. Chem., June 29, 2001; 276(27): 25014 - 25021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Morinaga, Y. Kaihou, N. Vitale, J. Moss, and M. Noda Involvement of ADP-ribosylation Factor 1 in Cholera Toxin-induced Morphological Changes of Chinese Hamster Ovary Cells J. Biol. Chem., June 15, 2001; 276(25): 22838 - 22843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Van Valkenburgh, J. F. Shern, J. D. Sharer, X. Zhu, and R. A. Kahn ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) Have Both Specific and Shared Effectors. CHARACTERIZING ARL1-BINDING PROTEINS J. Biol. Chem., June 15, 2001; 276(25): 22826 - 22837. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
