| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 259, Issue 13, 8066-8069, 07, 1984
WH Moolenaar, LG Tertoolen and SW de Laat
Addition of platelet-derived growth factor, epidermal growth factor, or serum to quiescent human fibroblasts, loaded with the fluorescent Ca2+ indicator quin-2, causes an immediate, up to 3-fold, rise in cytoplasmic free Ca2+ concentration [( Ca2+]i). In contrast, insulin and tumor-promoting phorbol ester have no effect on [Ca2+]i. The mitogen-induced [Ca2+]i response is initiated within a few s, reaches a maximum by 20-40 s, and then slowly declines to a new steady level. The [Ca2+]i response is not prevented by removal of external Ca2+ and is independent of the transmembrane Na+ gradient and membrane potential. It is concluded that platelet-derived growth factor, epidermal growth factor, and serum rapidly mobilize Ca2+ from intracellular stores, presumably due to the prior breakdown of inositol phospholipids, and that the resulting rise in [Ca2+]i may function as an initial signal in growth factor action.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Mitsuda, K. Furukawa, S. Fukumoto, H. Miyazaki, T. Urano, and K. Furukawa Overexpression of Ganglioside GM1 Results in the Dispersion of Platelet-derived Growth Factor Receptor from Glycolipid-enriched Microdomains and in the Suppression of Cell Growth Signals J. Biol. Chem., March 22, 2002; 277(13): 11239 - 11246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Liu, Y.-s. Ying, and R. G. W. Anderson Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae PNAS, December 9, 1997; 94(25): 13666 - 13670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Albrecht and J. G. Tidball Platelet-derived Growth Factor-stimulated Secretion of Basement Membrane Proteins by Skeletal Muscle Occurs by Tyrosine Kinase-dependent and -independent Pathways J. Biol. Chem., January 24, 1997; 272(4): 2236 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Ueno, H Colbert, J. Escobedo, and L. Williams Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor Science, May 10, 1991; 252(5007): 844 - 848. [Abstract] [PDF]
|
|
|
|
|
|
T. Hill, N. Dean, L. Mordan, A. Lau, M. Kanemitsu, and A. Boynton PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis Science, June 29, 1990; 248(4963): 1660 - 1663. [Abstract] [PDF]
|
|
|
|
|
|
C. Chen, M. Corbley, T. Roberts, and P Hess Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts Science, February 26, 1988; 239(4843): 1024 - 1026. [Abstract] [PDF]
|
|
|
|
|
|
E Rozengurt Early signals in the mitogenic response Science, October 10, 1986; 234(4773): 161 - 166. [Abstract] [PDF]
|
|
|
|
|
|
D Bar-Sagi and J. Feramisco Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science, September 5, 1986; 233(4768): 1061 - 1068. [Abstract] [PDF]
|
|
|
|
|
|
B. Berk, R. Alexander, T. Brock, M. Gimbrone Jr, and R. Webb Vasoconstriction: a new activity for platelet-derived growth factor Science, April 4, 1986; 232(4746): 87 - 90. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
