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J. Biol. Chem., Vol. 259, Issue 15, 9341-9344, Aug, 1984

Ca2+-calmodulin-dependent protein kinase in neuronal nuclei

N Sahyoun, H LeVine 3d, D Bronson and P Cuatrecasas

Ca2+-calmodulin-dependent protein kinase represents a major enzyme activity in neuronal nuclei. Most of the protein kinase activity is associated with the nuclear matrix but it can phosphorylate a broad range of substrates which derive from different nuclear compartments. Notable among these substrates is a Mr = 50,000 component of the nuclear matrix and a high mobility group chromatin protein which behaves like HMG17. The high level of activity, age- and tissue- specificity, and sensitivity to low concentrations of calmodulin suggest a role for this Ca2+-calmodulin-dependent protein kinase in regulating neuronal function at the level of the nucleus.
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