HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Parker, D. S. Articles by Pisano, J. J. Search for Related Content PubMed PubMed Citation Articles by Parker, D. S. Articles by Pisano, J. J. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 259, Issue 19, 11751-11755, Oct, 1984

Amino acid sequences of helospectins, new members of the glucagon superfamily, found in Gila monster venom

DS Parker, JP Raufman, TL O'Donohue, M Bledsoe, H Yoshida and JJ Pisano

The amino acid sequences of two closely related peptides from Gila monster (Heloderma suspectum) venom are reported. Helospectin I is a 38- residue peptide, His-Ser-Asp-Ala-Thr-Phe-Thr-Ala-Glu-Tyr-Ser-Lys-Leu- Leu-Ala-Lys-Leu-Ala- Leu-Gln - Lys-Tyr-Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser- Thr-Ser-Pro-Arg-Pro-Pro-Ser-Ser, and helospectin II is a 37-residue peptide identical to helospectin I except that it lacks serine 38. Helospectins are pancreatic secretagogues with structures and bioactivities similar to vasoactive intestinal peptide and other members of the glucagon superfamily. The relative significance of helospectin-I and helospectin-II is presently unknown. Comparison of the 28 residues of vasoactive intestinal peptide with residues 1-28 of helospectin shows that identical amino acids occur in 15 positions. Since members of the glucagon superfamily have similar structures but different biological actions, it is possible that helospectin is more closely related to a mammalian peptide awaiting discovery.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Olsson Distribution and effects of PACAP, VIP, nitric oxide and GABA in the gut of the African clawed frog Xenopus laevis J. Exp. Biol., April 15, 2002; 205(8): 1123 - 1134. [Abstract] [Full Text] [PDF]

				N. M. Sherwood, S. L. Krueckl, and J. E. McRory The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon Superfamily Endocr. Rev., December 1, 2000; 21(6): 619 - 670. [Abstract] [Full Text]

				M. Pohl and S. A. Wank Molecular Cloning of the Helodermin and Exendin-4 cDNAs in the Lizard. RELATIONSHIP TO VASOACTIVE INTESTINAL POLYPEPTIDE/PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE AND GLUCAGON-LIKE PEPTIDE 1 AND EVIDENCE AGAINST THE EXISTENCE OF MAMMALIAN HOMOLOGUES J. Biol. Chem., April 17, 1998; 273(16): 9778 - 9784. [Abstract] [Full Text] [PDF]