| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 259, Issue 2, 815-819, Jan, 1984
AC Ross, KJ Go, JG Heider and GH Rothblat
Compound 58-035 (3-[decyldimethylsilyl]-N-[2-(4-methylphenyl)-1- phenylethyl]pro panamide) has been found to inhibit the accumulation of cholesteryl esters in both rat hepatoma (Fu5AH) cells and arterial smooth muscle cells in culture. To explore the specificity of 58-035, we have studied the esterification of cholesterol, retinol, and glycerides by the Fu5AH cell and by isolated membranes. Exposure of Fu5AH to cholesterol/phospholipid dispersions and 58-035 (greater than 100 ng/ml) for 24 h resulted in greater than 95% inhibition of cholesterol esterification while cellular free cholesterol increased slightly. Inhibition was also rapid; incorporation of [3H]oleate into cholesteryl [3H]oleate equaled only 12% of control value after 30 min with 58-035 at 5 micrograms/ml. In contrast, there was no decrease in [3H]oleate incorporation into phospholipids or diglycerides, nor was the esterification of [3H]retinol inhibited by 58-035. In microsomal fractions, acyl-CoA:cholesterol acyltransferase could be inhibited completely by 58-035, while activities of acyl-CoA: retinol acyltransferase and triglyceride synthesis proceeded at 75-100% of control values. These observations that 58-035 is highly selective allow the inference that acyl-CoA:cholesterol acyltransferase is a separate microsomal enzyme whose activity can be modulated independently from acyl-CoA:retinol acyltransferase and other cellular acyltransferases.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Cui, E. Thorp, Y. Li, N. Wang, L. Yvan-Charvet, A. R. Tall, and I. Tabas Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells J. Leukoc. Biol., November 1, 2007; 82(5): 1040 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li and I. Tabas The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis J. Leukoc. Biol., February 1, 2007; 81(2): 483 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bao, Y. Li, S.-X. Deng, D. Landry, and I. Tabas Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages J. Biol. Chem., November 3, 2006; 281(44): 33635 - 33649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. de Medina, N. Boubekeur, P. Balaguer, G. Favre, S. Silvente-Poirot, and M. Poirot The Prototypical Inhibitor of Cholesterol Esterification, Sah 58-035 [3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], Is an Agonist of Estrogen Receptors J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 139 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-P. Tam, L. Mok, G. Chimini, M. Vasa, and R. G. Deeley ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells Am J Physiol Cell Physiol, September 1, 2006; 291(3): C490 - C502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lee-Rueckert, R. Vikstedt, J. Metso, C. Ehnholm, P. T. Kovanen, and M. Jauhiainen Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells J. Lipid Res., August 1, 2006; 47(8): 1725 - 1732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Boullier, Y. Li, O. Quehenberger, W. Palinski, I. Tabas, J. L. Witztum, and Y. I. Miller Minimally Oxidized LDL Offsets the Apoptotic Effects of Extensively Oxidized LDL and Free Cholesterol in Macrophages Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 1169 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, M.-C. Gerbod-Giannone, H. Seitz, D. Cui, E. Thorp, A. R. Tall, G. K. Matsushima, and I. Tabas Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor J. Biol. Chem., March 10, 2006; 281(10): 6707 - 6717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. DeVries-Seimon, Y. Li, P. M. Yao, E. Stone, Y. Wang, R. J. Davis, R. Flavell, and I. Tabas Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor J. Cell Biol., October 10, 2005; 171(1): 61 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Freeman, A. E. Rusinol, M. Linton, D. L. Hachey, S. Fazio, M. S. Sinensky, and D. Thewke Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages J. Lipid Res., September 1, 2005; 46(9): 1933 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, R. F. Schwabe, T. DeVries-Seimon, P. M. Yao, M.-C. Gerbod-Giannone, A. R. Tall, R. J. Davis, R. Flavell, D. A. Brenner, and I. Tabas Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-{alpha} and Interleukin-6: MODEL OF NF-{kappa}B- AND MAP KINASE-DEPENDENT INFLAMMATION IN ADVANCED ATHEROSCLEROSIS J. Biol. Chem., June 10, 2005; 280(23): 21763 - 21772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, M. Ge, L. Ciani, G. Kuriakose, E. J. Westover, M. Dura, D. F. Covey, J. H. Freed, F. R. Maxfield, J. Lytton, et al. Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids: IMPLICATIONS FOR DEPLETION OF ENDOPLASMIC RETICULUM CALCIUM STORES AND APOPTOSIS IN CHOLESTEROL-LOADED MACROPHAGES J. Biol. Chem., August 27, 2004; 279(35): 37030 - 37039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. de Medina, B. L. Payre, J. Bernad, I. Bosser, B. Pipy, S. Silvente-Poirot, G. Favre, J.-C. Faye, and M. Poirot Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 1165 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Leventhal, C. C. Leslie, and I. Tabas Suppression of Macrophage Eicosanoid Synthesis by Atherogenic Lipoproteins Is Profoundly Affected by Cholesterol-Fatty Acyl Esterification and the Niemann-Pick C Pathway of Lipid Trafficking J. Biol. Chem., February 27, 2004; 279(9): 8084 - 8092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Roitelman, D. Masson, R. Avner, C. Ammon-Zufferey, A. Perez, Y. Guyon-Gellin, C. L. Bentzen, and E. J. Niesor Apomine, a Novel Hypocholesterolemic Agent, Accelerates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase and Stimulates Low Density Lipoprotein Receptor Activity J. Biol. Chem., February 20, 2004; 279(8): 6465 - 6473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Feng and I. Tabas ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages. MECHANISM INVOLVES ENHANCED ABCA1 DEGRADATION IN A PROCESS REQUIRING FULL NPC1 ACTIVITY J. Biol. Chem., November 1, 2002; 277(45): 43271 - 43280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Skeggs and R. E. Morton LDL and HDL enriched in triglyceride promote abnormal cholesterol transport J. Lipid Res., August 1, 2002; 43(8): 1264 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Yao and I. Tabas Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway J. Biol. Chem., November 2, 2001; 276(45): 42468 - 42476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Buton, Z. Mamdouh, R. Ghosh, H. Du, G. Kuriakose, N. Beatini, G. A. Grabowski, F. R. Maxfield, and I. Tabas Unique Cellular Events Occurring during the Initial Interaction of Macrophages with Matrix-retained or Methylated Aggregated Low Density Lipoprotein (LDL). PROLONGED CELL-SURFACE CONTACT DURING WHICH LDL-CHOLESTERYL ESTER HYDROLYSIS EXCEEDS LDL PROTEIN DEGRADATION J. Biol. Chem., November 5, 1999; 274(45): 32112 - 32121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Gillotte, M. Zaiou, S. Lund-Katz, G. M. Anantharamaiah, P. Holvoet, A. Dhoest, M. N. Palgunachari, J. P. Segrest, K. H. Weisgraber, G. H. Rothblat, et al. Apolipoprotein-mediated Plasma Membrane Microsolubilization. ROLE OF LIPID AFFINITY AND MEMBRANE PENETRATION IN THE EFFLUX OF CELLULAR CHOLESTEROL AND PHOSPHOLIPID J. Biol. Chem., January 22, 1999; 274(4): 2021 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kritharides, J. Upston, W. Jessup, and R. T. Dean Accumulation and metabolism of low density lipoprotein-derived cholesteryl linoleate hydroperoxide and hydroxide by macrophages J. Lipid Res., December 1, 1998; 39(12): 2394 - 2405. [Abstract] [Full Text]
|
|
|
|
|
|
I. Ishii, N. Yokoyama, M. Yanagimachi, N. Ashikawa, M. Hata, S. Murakami, Y. Asami, N. Morisaki, Y. Saito, S. Ohmori, et al. Stimulation of Cholesterol Release from Rabbit Foam Cells by the Action of a New Inhibitor for Acyl CoA:Cholesterol Acyltransferase (ACAT), HL-004 J. Pharmacol. Exp. Ther., October 1, 1998; 287(1): 115 - 121. [Abstract] [Full Text]
|
|
|
|
|
|
J. Higaki, S. Hara, N. Takasu, K. Tonda, K. Miyata, T. Shike, K. Nagata, and T. Mizui Inhibition of Ileal Na+/Bile Acid Cotransporter by S-8921 Reduces Serum Cholesterol and Prevents Atherosclerosis in Rabbits Arterioscler. Thromb. Vasc. Biol., August 1, 1998; 18(8): 1304 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Rinninger, T. Kaiser, W. A. Mann, N. Meyer, H. Greten, and U. Beisiegel Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture J. Lipid Res., July 1, 1998; 39(7): 1335 - 1348. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Scheek, M. S. Brown, and J. L. Goldstein Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1 PNAS, October 14, 1997; 94(21): 11179 - 11183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ji, B. Jian, N. Wang, Y. Sun, M. d. l. L. Moya, M. C. Phillips, G. H. Rothblat, J. B. Swaney, and A. R. Tall Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux J. Biol. Chem., August 22, 1997; 272(34): 20982 - 20985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yang, D. Cromley, H. Wang, J. T. Billheimer, and S. L. Sturley Functional Expression of a cDNA to Human Acyl-coenzyme A:Cholesterol Acyltransferase in Yeast. SPECIES-DEPENDENT SUBSTRATE SPECIFICITY AND INHIBITOR SENSITIVITY J. Biol. Chem., February 14, 1997; 272(7): 3980 - 3985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Keesler, B. R. Gabel, C. M. Devlin, M. L. Koschinsky, and I. Tabas The Binding Activity of the Macrophage Lipoprotein(a)/Apolipoprotein(a) Receptor Is Induced by Cholesterol via a Post-translational Mechanism and Recognizes Distinct Kringle Domains on Apolipoprotein(a) J. Biol. Chem., December 13, 1996; 271(50): 32096 - 32104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tabas, S. Marathe, G. A. Keesler, N. Beatini, and Y. Shiratori Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis. PROPOSED ROLE OF AN EVENTUAL FAILURE OF THIS RESPONSE IN FOAM CELL NECROSIS IN ADVANCED ATHEROSCLEROSIS J. Biol. Chem., September 13, 1996; 271(37): 22773 - 22781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Yancey, W. V. Rodrigueza, E. P.C. Kilsdonk, G. W. Stoudt, W. J. Johnson, M. C. Phillips, and G. H. Rothblat Cellular Cholesterol Efflux Mediated by Cyclodextrins. DEMONSTRATION OF KINETIC POOLS AND MECHANISM OF EFFLUX J. Biol. Chem., July 5, 1996; 271(27): 16026 - 16034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Skiba, X. Zha, F. R. Maxfield, S. L. Schissel, and I. Tabas The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent J. Biol. Chem., June 7, 1996; 271(23): 13392 - 13400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, I. Tabas, R. Winchester, S. Ravalli, L. E. Rabbani, and A. Tall Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma J. Biol. Chem., April 12, 1996; 271(15): 8837 - 8842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Klansek, G. J. Warner, W. J. Johnson, and J. M. Glick Compartmental Isolation of Cholesterol Participating in the Cytoplasmic Cholesteryl Ester Cycle in Chinese Hamster Ovary 25-RA Cells J. Biol. Chem., March 1, 1996; 271(9): 4923 - 4929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shiratori, M. Houweling, X. Zha, and I. Tabas Stimulation of CTP:Phosphocholine Cytidylyltransferase by Free Cholesterol Loading of Macrophages Involves Signaling through Protein Dephosphorylation J. Biol. Chem., December 15, 1995; 270(50): 29894 - 29903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Johnson, R. T. Fischer, M. C. Phillips, and G. H. Rothblat Efflux of Newly Synthesized Cholesterol and Biosynthetic Sterol Intermediates from Cells J. Biol. Chem., October 20, 1995; 270(42): 25037 - 25046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Warner, G. Stoudt, M. Bamberger, W. J. Johnson, and G. H. Rothblat Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol J. Biol. Chem., March 17, 1995; 270(11): 5772 - 5778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kritharides, W. Jessup, E. L. Mander, and R. T. Dean Apolipoprotein A-I–Mediated Efflux of Sterols From Oxidized LDL–Loaded Macrophages Arterioscler. Thromb. Vasc. Biol., February 1, 1995; 15(2): 276 - 289. [Abstract] [Full Text]
|
|
|
|
|
|
P. M. Yao and I. Tabas Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway J. Biol. Chem., July 28, 2000; 275(31): 23807 - 23813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhang, W. Tang, P. M. Yao, C. Yang, B. Xie, S. Jackowski, and I. Tabas Macrophages Deficient in CTP:Phosphocholine Cytidylyltransferase-alpha Are Viable under Normal Culture Conditions but Are Highly Susceptible to Free Cholesterol-induced Death. MOLECULAR GENETIC EVIDENCE THAT THE INDUCTION OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN FREE CHOLESTEROL-LOADED MACROPHAGES IS AN ADAPTIVE RESPONSE J. Biol. Chem., November 3, 2000; 275(45): 35368 - 35376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sonda, L.-M. Ting, S. Novak, K. Kim, J. J. Maher, R. V. Farese Jr., and J. D. Ernst Cholesterol Esterification by Host and Parasite Is Essential for Optimal Proliferation of Toxoplasma gondii J. Biol. Chem., September 7, 2001; 276(37): 34434 - 34440. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
