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J. Biol. Chem., Vol. 259, Issue 21, 13151-13158, Nov, 1984
N Ikemoto, B Antoniu and DH Kim
Rapid replacement of 0.15 M K gluconate with 0.15 M choline Cl led to
multiphasic Ca2+ release from a heavy fraction of rabbit skeletal muscle
microsomes. Following the initial lag period (0-50 ms), about 15 nmol of
Ca2+/mg of protein was rapidly released with first-order rate constants k =
60-140 s-1. Subsequently, a larger amount of Ca2+ (up to 56 nmol/mg) was
released at a slower rate (k = 0.8-1.5 s-1). The Ca2+ released in both
rapid and slow phases was reaccumulated within 60 s. In agreement with a
previous report (Caswell, A. H., Lau, Y. H., Garcia, M., and Brunschwig,
J-P. (1979) J. Biol. Chem. 254, 202-208), French press treatment of the
tubule/sarcoplasmic reticulum (SR) complex results in dissociation of
transverse tubular membrane (T- tubules) from SR. Subsequent incubation
with 0.4 M potassium cacodylate results in the reassociation of the
complex, as shown by sucrose density-gradient sedimentation. Upon T-tubule
dissociation, both rapid and slow Ca2+ release was inhibited. Upon
reassociation, the rapid Ca2+ release was completely restored and the slow
phase partially restored. The results indicate that the T-tubule associated
with SR plays a crucial role in triggering rapid Ca2+ release induced by
ionic replacement. Other types of Ca2+ release, e.g. those induced by Ca2+
alone or with drugs such as caffeine and quercetin, are unaffected by T-
tubule dissociation, and hence produced by direct stimulation of the SR
membrane.
Rapid calcium release from the isolated sarcoplasmic reticulum is triggered via the attached transverse tubular system
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