J. Biol. Chem., Vol. 259, Issue 23, 14437-14440, Dec, 1984

Metabolism of leukotrienes B4 and C4 in the isolated perfused rat lung

TW Harper, JY Westcott, N Voelkel and RC Murphy

Isolated rat lungs perfused with physiological buffer containing leukotriene C4 were found to rapidly metabolize leukotriene C4 to leukotriene C4 sulfoxide, leukotriene D4, and leukotriene E4. Addition of leukotriene C4 to the recirculating perfusion buffer was observed to cause a persistent increase in the pulmonary arterial pressure. Leukotriene C4 instilled into the airway of the perfused lung was also rapidly metabolized to these same products with retention of the products within the lung. In contrast, leukotriene B4 injected into the perfusion fluid was recovered unchanged in the lung effluent. Leukotriene B4 instilled into the airway of the perfused lung was observed to rapidly traverse the alveolar membranes and was recovered intact in the lung effluent. No evidence for formation of the 20- hydroxy or the 20-carboxy metabolites of leukotriene B4 by the isolated perfused rat lung was observed.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				F. Grimminger, K. Mayer, L. Kiss, D. Walmrath, and W. Seeger PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L268 - L275. [Abstract] [Full Text] [PDF]

				J. A. HANKIN and R. C. MURPHY The Metabolism of Leukotriene B4 in Lewis Lung Carcinoma Porcine Kidney Cells Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): S81 - 87. [Full Text] [PDF]