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J. Biol. Chem., Vol. 259, Issue 24, 15078-15084, Dec, 1984

Na+ modulates the affinity of the lutropin/choriogonadotropin receptor

K Buettner and M Ascoli

The studies presented herein were designed to assess the effects of Na+ on the affinity of the lutropin/choriogonadotropin (LH/CG) receptor. We performed competition binding experiments in buffers containing NaCl or an isosmolar concentration of an appropriate Na+ substitute. The results presented show that Na+ decreases the affinity of LH, but not that of CG, in intact cells and membranes. In detergent-solubilized receptors, however, the affinity of LH is higher than that of CG and is not influenced by Na+. In addition, we show that Na+ does not affect the number of LH/CG receptors.
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