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J. Biol. Chem., Vol. 260, Issue 10, 5860-5862, 05, 1985

Electrostatic deformation of DNA by a DNA-binding protein

JB Matthew and DH Ohlendorf

Complementary electrostatic interactions between negatively charged B- DNA and a positively charged array on the lambda Cro repressor protein are shown to substantially contribute to the formation energy of sequence-specific and nonspecific Cro-DNA complexes. The electrostatic interactions favor Cro binding to a bent form of DNA, a geometry which optimizes hydrogen-bonding contacts between Cro and exposed base pair groups in the DNA major groove.
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