HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lim, L. K. Articles by Kaslow, H. R. Search for Related Content PubMed PubMed Citation Articles by Lim, L. K. Articles by Kaslow, H. R. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 260, Issue 5, 2585-2588, Mar, 1985

Adenine nucleotides directly stimulate pertussis toxin

LK Lim, RD Sekura and HR Kaslow

Both cholera toxin and pertussis toxin catalyzed ADP-ribosylation of purified bovine brain tubulin. The effect of cholera toxin was evident in the absence or presence of nucleotides. In contrast, pertussis toxin required adenine nucleotides for its ADP-ribosylating activity. ATP, ATP gamma S, App(NH)p, deoxy-ATP, and ADP all supported pertussis toxin- catalyzed ADP-ribosylations in the absence or presence of EDTA, suggesting that nucleotide hydrolysis was not involved. Adenine nucleotides also promoted pertussis toxin-catalyzed ADP-ribosylation of heat-treated bovine serum albumin. This result suggests that adenine nucleotides directly affect pertussis toxin. ATP stimulation of pertussis toxin-catalyzed hydrolysis of NAD to ADP-ribose supports this hypothesis.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. W. Mesner Jr., K. C. Bible, L. M. Martins, T. J. Kottke, S. M. Srinivasula, P. A. Svingen, T. J. Chilcote, G. S. Basi, J. S. Tung, S. Krajewski, et al. Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions. NUCLEOTIDE REQUIREMENT AND INHIBITOR PROFILE J. Biol. Chem., August 6, 1999; 274(32): 22635 - 22645. [Abstract] [Full Text] [PDF]