HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sabate, M. I. Articles by Rosenfeld, M. G. Search for Related Content PubMed PubMed Citation Articles by Sabate, M. I. Articles by Rosenfeld, M. G. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 260, Issue 5, 2589-2592, 03, 1985

Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells

MI Sabate, LS Stolarsky, JM Polak, SR Bloom, IM Varndell, MA Ghatei, RM Evans and MG Rosenfeld

The generation of two discrete mRNAs encoding different polypeptide products in expression of the rat calcitonin, CGRP gene provides an example of developmentally determined alternative RNA processing events in the neuroendocrine system. Both mature mRNA transcripts and their peptide products, encoding either calcitonin or calcitonin gene-related peptide (CGRP) are co-produced in identical thyroid C-cells, in a ratio of 95:1, respectively. These data suggest that the generation of the two mRNAs reflect the actions of a factor(s) dictating alternative RNA processing events.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H.-L. Zhou, A. P. Baraniak, and H. Lou Role for Fox-1/Fox-2 in Mediating the Neuronal Pathway of Calcitonin/Calcitonin Gene-Related Peptide Alternative RNA Processing Mol. Cell. Biol., February 1, 2007; 27(3): 830 - 841. [Abstract] [Full Text] [PDF]

				J. R. ROESSER Both U2 snRNA and U12 snRNA are required for accurate splicing of exon 5 of the rat calcitonin/CGRP gene RNA, August 1, 2004; 10(8): 1243 - 1250. [Abstract] [Full Text] [PDF]

				J. Qiu, R. Nayak, and D. J. Pintel Alternative Polyadenylation of Adeno-Associated Virus Type 5 RNA within an Internal Intron Is Governed by both a Downstream Element within the Intron 3' Splice Acceptor and an Element Upstream of the P41 Initiation Site J. Virol., January 1, 2004; 78(1): 83 - 93. [Abstract] [Full Text] [PDF]

				K. Minemura, T. Takeda, K. Minemura, T. Nagasawa, R. Zhang, R. Leopardi, and L. J. DeGroot Cell-Specific Induction of Sensitivity to Ganciclovir in Medullary Thyroid Carcinoma Cells by Adenovirus-Mediated Gene Transfer of Herpes Simplex Virus Thymidine Kinase Endocrinology, May 1, 2000; 141(5): 1814 - 1822. [Abstract] [Full Text] [PDF]

				J. Zhao, L. Hyman, and C. Moore Formation of mRNA 3' Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis Microbiol. Mol. Biol. Rev., June 1, 1999; 63(2): 405 - 445. [Abstract] [Full Text] [PDF]

				C. Gennari, R. Nami, S. Pecchi, V. De Franco, F. Panza, and G. Pavese Plethysmographic Evaluation of the Vascular Effects of Human Calcitonin Gene-Related Peptide in Man Angiology, June 1, 1991; 42(6): 462 - 467. [Abstract] [PDF]

				R N Nagoshi and B S Baker Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. Genes & Dev., January 1, 1990; 4(1): 89 - 97. [Abstract] [PDF]