HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moyer, J. D. Articles by Ayers, O. Search for Related Content PubMed PubMed Citation Articles by Moyer, J. D. Articles by Ayers, O. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 260, Issue 5, 2812-2818, Mar, 1985

Salvage of circulating pyrimidine nucleosides by tissues of the mouse

JD Moyer, N Malinowski and O Ayers

The metabolism of pyrimidine nucleosides present in the plasma of the mouse has been examined. Uridine and cytidine are rapidly cleared from the circulation with t1/2 of less than 5 min. Uracil, deoxycytidine, deoxyuridine, and thymidine are cleared more slowly with t1/2 of 9 to 13 min. Various tissues differed markedly in the extent of nucleotide formation from circulating nucleosides. Cytidine and uridine are predominantly converted to nucleotides (greater than 50%) rather than catabolized, whereas uracil is almost entirely degraded. Thymidine, deoxyuridine, and deoxycytidine are intermediate in the extent of their conversion to nucleotides: 8.9 to 21% of these nucleosides are salvaged in the mouse. Both anabolic and catabolic routes are important in the metabolism of pyrimidine nucleosides in vivo.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Kenzelmann, S. Maertens, M. Hergenhahn, S. Kueffer, A. Hotz-Wagenblatt, L. Li, S. Wang, C. Ittrich, T. Lemberger, R. Arribas, et al. Microarray analysis of newly synthesized RNA in cells and animals PNAS, April 10, 2007; 104(15): 6164 - 6169. [Abstract] [Full Text] [PDF]