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J. Biol. Chem., Vol. 261, Issue 15, 6747-6757, May, 1986
PP Minghetti, DE Ruffner, WJ Kuang, OE Dennison, JW Hawkins, WG Beattie and A Dugaiczyk
The human albumin gene spans 16,961 nucleotides from the putative "Cap"
site to the first poly(A) addition site. It is split into 15 exons by 14
intervening sequences which are symmetrically placed within the three
domains of albumin. The 5' region is highly conserved up to position -250
and contains the putative TATA (-32) and CAT (-88) boxes. A consensus 5'
splice sequence reads /GTAGAGT while the 3' splice sequence is pyrimidine
rich and contains CTAG/ at the splice junction. The gene contains three
polyadenylation signals, and this 3' region presumably arose by
triplication of a shorter fragment prior to mammalian radiation. The
albumin gene exhibits a high degree of DNA polymorphism and appears to have
been recently invaded by Alu repetitive sequences.
Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4
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