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J. Biol. Chem., Vol. 261, Issue 31, 14539-14544, 11, 1986
PK Lund, BM Moats-Staats, MA Hynes, JG Simmons, M Jansen, AJ D'Ercole and JJ Van Wyk
Somatomedin-C or insulin-like growth factor I (Sm-C/IGF-I) and insulin-
like growth factor II (IGF-II) have been implicated in the regulation of
fetal growth and development. In the present study 32P-labeled
complementary DNA probes encoding human and mouse Sm-C/IGF-I and human
IGF-II were used in Northern blot hybridizations to analyse rat Sm- C/IGF-I
and IGF-II mRNAs in poly(A+) RNAs from intestine, liver, lung, and brain of
adult rats and fetal rats between day 14 and 17 of gestation. In fetal
rats, all four tissues contained a major mRNA of 1.7 kilobases (kb) that
hybridized with the human Sm-C/IGF-I cDNA and mRNAs of 7.5, 4.7, 1.7, and
1.2 kb that hybridized with the mouse Sm- C/IGF-I cDNA. Adult rat
intestine, liver, and lung also contained these mRNAs but Sm-C/IGF-I mRNAs
were not detected in adult rat brain. These findings provide direct support
for prior observations that multiple tissues in the fetus synthesize
immunoreactive Sm-C/IGF-I and imply a role for Sm-C/IGF-I in fetal
development as well as postnatally. The abundance of a 7.5-kb Sm-C/IGF-I
mRNA in poly(A+) RNAs from adult rat liver was 10-50-fold higher than in
other adult rat tissues which provides further evidence that in the adult
rat the liver is a major site of Sm-C/IGF-I synthesis and source of
circulating Sm-C/IGF-I. Multiple IGF-II mRNAs of estimated sizes 4.7, 3.9,
2.2, 1.75, and 1.2 kb were observed in fetal rat intestine, liver, lung,
and brain. The 4.7- and 3.9-kb mRNAs were the major hybridizing IGF-II
mRNAs in all fetal tissues. Higher abundance of IGF-II mRNAs in rat fetal
tissues compared with adult tissues supports prior hypotheses, based on
serum IGF-II concentrations, that IGF-II is predominantly a fetal
somatomedin. IGF-II mRNAs are present, however, in some poly(A+) RNAs from
adult rat tissues. The brain was the only tissue in the adult rat where the
4.7- and 3.9-kb IGF-II mRNAs were consistently detected. Some samples of
adult rat intestine contained the 4.7- and 3.9-kb IGF-II mRNAs and some
samples of adult liver and lung contained the 4.7-kb mRNA. These findings
suggest that a role for IGF-II in the adult rat, particularly in the
central nervous system, cannot be excluded.
Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues
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