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J. Biol. Chem., Vol. 261, Issue 4, 1677-1686, 02, 1986
SK Hollingshead, VA Fischetti and JR Scott
The DNA sequence of the gene for type 6 M protein of Streptococcus pyogenes
contains two extended tandem repeat regions and one nontandem repeat
region. We suggest that the duplication and deletion of these repeats
generates the observed diversity in size and sequence among the family of M
proteins in the group A streptococci. In addition, the DNA sequence reveals
the presence of a 42-amino-acid signal peptide, a region rich in proline
that is thought to be located in the cell wall, and a membrane anchor
sequence at the carboxyl-terminal end of the protein. Signals similar to
the consensus sequences recognized for the initiation of transcription and
translation in Gram-positive bacteria have been identified in the DNA
sequence. Codon usage is similar to that of other Gram-positive bacteria
and significantly different from that of Escherichia coli.
Complete nucleotide sequence of type 6 M protein of the group A Streptococcus. Repetitive structure and membrane anchor
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