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J. Biol. Chem., Vol. 262, Issue 11, 5394-5397, 04, 1987
PN Cockerill, MH Yuen and WT Garrard
We have located presumptive chromosomal loop anchorage elements within the
mouse heavy chain immunoglobulin locus. Analysis of 31 kilobases spanning
diversity, joining, enhancer, switch, and the mu and delta constant regions
reveals that only a single 1-kilobase segment exhibits specific binding to
nuclear matrices. It is of particular significance that the transcriptional
enhancer element resides within this matrix association region (MAR). Fine
structure mapping indicates that binding is mediated by A+T-rich
approximately 350-base pair segments that reside on either side of the
enhancer. The MAR sequences residing 5' of the enhancer contain
topoisomerase II consensus sequences like the MAR located upstream of the
kappa light chain gene enhancer. The heavy chain gene MARs, however,
exhibit a lower affinity for matrix association compared to the kappa gene
MAR. Significantly, the juxtaposition of enhancer elements with MARs
appears to be evolutionarily conserved within the immunoglobulin genes,
suggesting that MARs may act as positive and/or negative regulators of
enhancer function.
The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements
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