| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 262, Issue 17, 7943-7946, 06, 1987
AT Leung, T Imagawa and KP Campbell
The 1,4-dihydropyridine receptor purified from rabbit skeletal muscle
triads was shown to contain four protein components of 175,000, 170,000,
52,000, and 32,000 Da when analyzed by sodium dodecyl sulfate-
polyacrylamide gel electrophoresis under nonreducing conditions. Monoclonal
antibodies capable of specifically immunoprecipitating the
[3H]PN200-110-labeled dihydropyridine receptor from digitonin- solubilized
triads recognized the 170,000-Da protein on nitrocellulose transfers of
skeletal muscle triads, transverse tubular membranes, and purified
dihydropyridine receptor. Wheat germ agglutinin peroxidase stained the
175,000-Da protein on similar nitrocellulose transfers, demonstrating that
the 175,000-Da protein is the glycoprotein subunit of the purified
dihydropyridine receptor. The apparent molecular weight of the Mr 170,000
protein remained unchanged with reduction, whereas the apparent molecular
weight of the glycoprotein subunit shifted from 175,000 to 150,000 upon
reduction. These results demonstrate that the 1,4-dihydropyridine receptor
of the voltage-dependent Ca2+ channel from rabbit skeletal muscle contains
two distinct high molecular weight subunits of 175,000 and 170,000.
Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  O. Delbono, J. Xia, S. Treves, Z.-M. Wang, R. Jimenez-Moreno, A. M. Payne, M. L. Messi, A. Briguet, F. Schaerer, M. Nishi, et al. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45 PNAS, December 11, 2007; 104(50): 20108 - 20113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sonkusare, M. Fraer, J. D. Marsh, and N. J. Rusch Disrupting Calcium Channel Expression To Lower Blood Pressure: New Targeting of a Well-Known Channel Mol. Interv., December 1, 2006; 6(6): 304 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-N. Yang and P.-O. Berggren The Role of Voltage-Gated Calcium Channels in Pancreatic {beta}-Cell Physiology and Pathophysiology Endocr. Rev., October 1, 2006; 27(6): 621 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Anderson, X. Altafaj, Z. Zheng, Z.-M. Wang, O. Delbono, M. Ronjat, S. Treves, and F. Zorzato The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1 J. Cell Sci., May 15, 2006; 119(10): 2145 - 2155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-G. Kang, C.-C. Chen, M. Wakamori, Y. Hara, Y. Mori, and K. P. Campbell A functional AMPA receptor-calcium channel complex in the postsynaptic membrane PNAS, April 4, 2006; 103(14): 5561 - 5566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Wang, R. F. Collins, R. C. Ford, N. S. Berrow, A. C. Dolphin, and A. Kitmitto The Three-dimensional Structure of the Cardiac L-type Voltage-gated Calcium Channel: COMPARISON WITH THE SKELETAL MUSCLE FORM REVEALS A COMMON ARCHITECTURAL MOTIF J. Biol. Chem., February 20, 2004; 279(8): 7159 - 7168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Arikkath, C.-C. Chen, C. Ahern, V. Allamand, J. D. Flanagan, R. Coronado, R. G. Gregg, and K. P. Campbell gamma 1 Subunit Interactions within the Skeletal Muscle L-type Voltage-gated Calcium Channels J. Biol. Chem., January 3, 2003; 278(2): 1212 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Neuhuber, U. Gerster, J. Mitterdorfer, H. Glossmann, and B. E. Flucher Differential Effects of Ca2+ Channel beta 1a and beta 2a Subunits on Complex Formation with alpha 1S and on Current Expression in tsA201 Cells J. Biol. Chem., April 10, 1998; 273(15): 9110 - 9118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Protasi, C. Franzini-Armstrong, and P. D. Allen Role of Ryanodine Receptors in the Assembly of Calcium Release Units in Skeletal Muscle J. Cell Biol., February 23, 1998; 140(4): 831 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. E. S. Scott, R. Felix, J. Arikkath, and K. P. Campbell Evidence for a 95 kDa Short Form of the alpha 1A Subunit Associated with the omega -Conotoxin MVIIC Receptor of the P/Q-type Ca2+ Channels J. Neurosci., January 15, 1998; 18(2): 641 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Gurnett, R. Felix, and K. P. Campbell Extracellular Interaction of the Voltage-dependent Ca2+ Channel alpha 2delta and alpha 1 Subunits J. Biol. Chem., July 18, 1997; 272(29): 18508 - 18512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Buck, H. T. Nguyen, I. N. Pessah, and P. D. Allen Dyspedic Mouse Skeletal Muscle Expresses Major Elements of the Triadic Junction but Lacks Detectable Ryanodine Receptor Protein and Function J. Biol. Chem., March 14, 1997; 272(11): 7360 - 7367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, R. Felix, C. A. Gurnett, M. De Waard, D. R. Witcher, and K. P. Campbell Expression and Subunit Interaction of Voltage-Dependent Ca2+ Channels in PC12 Cells J. Neurosci., December 1, 1996; 16(23): 7557 - 7565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Gee, J. P. Brown, V. U. K. Dissanayake, J. Offord, R. Thurlow, and G. N. Woodruff The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the alpha(2)[IMAGE] Subunit of a Calcium Channel J. Biol. Chem., March 8, 1996; 271(10): 5768 - 5776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. E. S. Scott, M. De Waard, H. Liu, C. A. Gurnett, D. P. Venzke, V. A. Lennon, and K. P. Campbell betaSubunit Heterogeneity in N-type Ca[IMAGE] Channels J. Biol. Chem., February 9, 1996; 271(6): 3207 - 3212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Witcher, M. D. Waard, H. Liu, M. Pragnell, and K. P. Campbell Association of Native Ca[IMAGE] Channel [IMAGE] Subunits with the [IMAGE][IMAGE] Subunit Interaction Domain J. Biol. Chem., July 28, 1995; 270(30): 18088 - 18093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Rotman, B. J. Murphy, and W. A. Catterall Sites of Selective cAMP-dependent Phosphorylation of the L-type Calcium Channel [IMAGE]1 Subunit from Intact Rabbit Skeletal Muscle Myotubes J. Biol. Chem., July 7, 1995; 270(27): 16371 - 16377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Guo and K. P. Campbell Association of Triadin with the Ryanodine Receptor and Calsequestrin in the Lumen of the Sarcoplasmic Reticulum J. Biol. Chem., April 21, 1995; 270(16): 9027 - 9030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Gurnett, S. D. Kahl, R. D. Anderson, and K. P. Campbell Absence of the Skeletal Muscle Sarcolemma Chloride Channel ClC-1 in Myotonic Mice J. Biol. Chem., April 21, 1995; 270(16): 9035 - 9038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Catterall Functional subunit structure of voltage-gated calcium channels Science, September 27, 1991; 253(5027): 1499 - 1500. [PDF]
|
|
|
|
|
|
P Ruth, A Rohrkasten, M Biel, E Bosse, S Regulla, H. Meyer, V Flockerzi, and F Hofmann Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle Science, September 8, 1989; 245(4922): 1115 - 1118. [Abstract] [PDF]
|
|
|
|
|
|
I Lotan, P Goelet, A Gigi, and N Dascal Specific block of calcium channel expression by a fragment of dihydropyridine receptor cDNA Science, February 3, 1989; 243(4891): 666 - 669. [Abstract] [PDF]
|
|
|
|
|
|
W. Catterall Structure and function of voltage-sensitive ion channels Science, October 7, 1988; 242(4875): 50 - 61. [Abstract] [PDF]
|
|
|
|
|
|
S. Ellis, M. Williams, N. Ways, R Brenner, A. Sharp, A. Leung, K. Campbell, E McKenna, W. Koch, A Hui, et al. Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel Science, September 23, 1988; 241(4873): 1661 - 1664. [Abstract] [PDF]
|
|
|
|
|
|
H. Lester Heterologous expression of excitability proteins: route to more specific drugs? Science, August 26, 1988; 241(4869): 1057 - 1063. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
