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J. Biol. Chem., Vol. 262, Issue 17, 8027-8034, 06, 1987
BA Evans, CC Drinkwater and RI Richards
Mouse glandular kallikreins are encoded by a family of closely linked genes
which are located on chromosome 7 at a site corresponding to the
genetically defined Tam-1, Prt-4, and Prt-5 loci. We have characterized 24
kallikrein genes by genomic cloning and restriction mapping of 310 kilobase
pairs of BALB/c mouse DNA. Most of these genes are highly homologous, have
the same exon/intron organization, and are linked in clusters of up to 11
genes. Partial sequence analysis of the kallikrein genes has facilitated
identification of those members of the family for which protein sequence
data exist and assignment of those which are pseudogenes or encode proteins
of unknown function. We find that a maximum of 14 mouse kallikrein genes
have the potential to encode functional proteins.
Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus
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