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J. Biol. Chem., Vol. 262, Issue 20, 9594-9600, Jul, 1987
CY Hsu and FR Frankel
Cytoplasmic beta- and gamma-actin mRNAs as well as smooth muscle actin
mRNAs have been shown to be transiently increased in rat uterus after
treatment with the steroid hormone estradiol. A clone isolated as an
estradiol-induced message from a lambda-gt10 cDNA library prepared from the
mRNA of estrogen-stimulated immature rat uterus was identified as
alpha-smooth muscle actin. A single-stranded RNA probe composed mainly of
the 3'-untranslated region of this clone, as well as DNA probes derived
from the 3'-untranslated regions of other actin genes, were used to study
the induction kinetics of different actin isoforms in rat uterus after
being stimulated by estradiol. The beta- and gamma- cytoskeletal actins
showed an induction peak at 4 h after estradiol administration with 1.4-
and 1.8-fold increases, respectively. The smooth muscle actin was maximally
increased 2.1-fold at 8-12 h. Messages of alpha-skeletal and alpha-cardiac
actins were neither expressed nor induced by estradiol in this tissue. The
different induction kinetics of the cytoplasmic and smooth muscle actins
suggest that they are regulated by different mechanisms and possibly in
different cell types of the uterus.
Effect of estrogen on the expression of mRNAs of different actin isoforms in immature rat uterus. Cloning of alpha-smooth muscle actin message
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