J. Biol. Chem., Vol. 262, Issue 21, 9931-9934, 07, 1987
DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene
DR Stanford, A Rohleder, K Neiswanger and ED Wieben
The sequence of a complementary DNA clone coding for a human autoimmune
antigen has been determined. This DNA sequence predicts the amino acid
sequence of a small protein ("E") which is associated with small nuclear
RNA in human cells. Analysis of the predicted protein sequence suggests
that the E protein is not closely related to other nucleic acid binding
proteins. Screening of a human genomic DNA library has led to the isolation
of several members of the E protein multigene family. Sequence analysis of
one member of this family reveals that it is flanked by direct repeats and
contains several mutations. One of these mutations, an insertion,
terminates the long open reading frame. These features are compatible with
the designation of this sequence as a processed pseudogene.
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