| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 262, Issue 3, 947-950, Jan, 1987
SC Lam, EF Plow, MA Smith, A Andrieux, JJ Ryckwaert, G Marguerie and MH Ginsberg
Synthetic peptides corresponding to the carboxyl terminus of the fibrinogen
gamma chain inhibit the binding of fibrinogen, fibronectin, and von
Willebrand factor to platelets, yet the active decapeptide sequence has
only been found in fibrinogen to date. In contrast, all three proteins
contain Arg-Gly-Asp sequences, and peptides containing Arg-Gly-Asp are
potent inhibitors of their binding to activated platelets. We have analyzed
the relationship between these peptide sets by direct binding assays. H12
(gamma 400-411) inhibited the binding of an Arg-Gly-Asp-containing peptide
to platelets with similar dose response to inhibition of fibronectin
binding. We have previously reported that GPIIb-IIIa binds to immobilized
Arg-Gly-Asp peptides and can be eluted by Arg-Gly-Asp-containing peptides
in solution. Both H12 and L10 (gamma 402-411) completely eluted GPIIb-IIIa
bound to immobilized Arg-Gly-Asp peptides. Conversely, when GPIIb-IIIa was
bound to immobilized L10, either L10 or an Arg-Gly-Asp peptide could elute
it. Peptide specificity was established by the failure of Gly-Arg-Gly-
Glu-Ser-Pro or acetylated L10 to elute GPIIb-IIIa from the immobilized
peptides. These results indicate that the two peptide sets interact with
the same receptor which contains GPIIb-IIIa.
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. A. Springer, J. Zhu, and T. Xiao Structural basis for distinctive recognition of fibrinogen {gamma}C peptide by the platelet integrin {alpha}IIb{beta}3 J. Cell Biol., August 25, 2008; 182(4): 791 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Blue, M. Murcia, C. Karan, M. Jirouskova, and B. S. Coller Application of high-throughput screening to identify a novel {alpha}IIb-specific small- molecule inhibitor of {alpha}IIb{beta}3-mediated platelet interaction with fibrinogen Blood, February 1, 2008; 111(3): 1248 - 1256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Pesho, K. Bledzka, L. Michalec, C. S. Cierniewski, and E. F. Plow The Specificity and Function of the Metal-binding Sites in the Integrin beta3 A-domain J. Biol. Chem., August 11, 2006; 281(32): 23034 - 23041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Choi, M. F. Khan, J. E. Leidenfrost, E. T. Collins, K. P. Boc, B. R. Villa, D. V. Novack, W. C. Parks, and D. R. Abendschein {beta}3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice Circulation, March 30, 2004; 109(12): 1564 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cierniewska-Cieslak, C. S. Cierniewski, K. Blecka, M. Papierak, L. Michalec, L. Zhang, T. A. Haas, and E. F. Plow Identification and Characterization of Two Cation Binding Sites in the Integrin beta 3 Subunit J. Biol. Chem., March 22, 2002; 277(13): 11126 - 11134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Rosado, E. M. Y. Meijer, K. Hamulyak, I. Novakova, J. W. M. Heemskerk, and S. O. Sage Fibrinogen binding to the integrin {alpha}IIb{beta}3 modulates store-mediated calcium entry in human platelets Blood, May 1, 2001; 97(9): 2648 - 2656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Ward, A. S. Kestin, and P. J. Newman A Leu262Pro mutation in the integrin beta 3 subunit results in an alpha IIb-beta 3 complex that binds fibrin but not fibrinogen Blood, July 1, 2000; 96(1): 161 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Beumer, G. J. Heijnen-Snyder, M. J. W. IJsseldijk, P. G. de Groot, and J. J. Sixma Fibronectin in an Extracellular Matrix of Cultured Endothelial Cells Supports Platelet Adhesion via Its Ninth Type III Repeat : A Comparison With Platelet Adhesion to Isolated Fibronectin Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20 (4): e16 - e25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jedsadayanmata, C.-C. Chen, M. L. Kireeva, L. F. Lau, and S. C.-T. Lam Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin alpha IIbbeta 3 J. Biol. Chem., August 20, 1999; 274(34): 24321 - 24327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Cierniewski, T. Byzova, M. Papierak, T. A. Haas, J. Niewiarowska, L. Zhang, M. Cieslak, and E. F. Plow Peptide Ligands Can Bind to Distinct Sites in Integrin alpha IIbbeta 3 and Elicit Different Functional Responses J. Biol. Chem., June 11, 1999; 274(24): 16923 - 16932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Hu, C. A. White, S. Panzer-Knodle, J. D. Page, N. Nicholson, and J. W. Smith A New Model of Dual Interacting Ligand Binding Sites on Integrin alpha IIbbeta 3 J. Biol. Chem., February 19, 1999; 274(8): 4633 - 4639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Tozer, E. K. Baker, M. H. Ginsberg, and J. C. Loftus A Mutation in the alpha Subunit of the Platelet Integrin alpha IIbbeta 3 Identifies a Novel Region Important for Ligand Binding Blood, February 1, 1999; 93(3): 918 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. O'Connell, T. Nanavaty, D. McDevitt, S. Gurusiddappa, M. Hook, and T. J. Foster The Fibrinogen-binding MSCRAMM (Clumping Factor) of Staphylococcus aureus Has a Ca2+-dependent Inhibitory Site J. Biol. Chem., March 20, 1998; 273(12): 6821 - 6829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, G. W. Wong, N. Ghildyal, M. F. Gurish, A. Sali, R. Matsumoto, W.-T. Qiu, and R. L. Stevens The Tryptase, Mouse Mast Cell Protease 7, Exhibits Anticoagulant Activity in Vivo and in Vitro Due to Its Ability to Degrade Fibrinogen in the Presence of the Diverse Array of Protease Inhibitors in Plasma J. Biol. Chem., December 12, 1997; 272(50): 31885 - 31893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Tselepis, L. J. Green, and M. J. Humphries An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity. EVIDENCE FOR A FUNCTIONAL EQUIVALENCE OF ACIDIC INTEGRIN-BINDING MOTIFS J. Biol. Chem., August 22, 1997; 272(34): 21341 - 21348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Faull, J. Wang, D. I. Leavesley, W. Puzon, G. R. Russ, D. Vestweber, and Y. Takada A Novel Activating Anti-beta 1 Integrin Monoclonal Antibody Binds to the Cysteine-rich Repeats in the beta 1 Chain J. Biol. Chem., October 11, 1996; 271(41): 25099 - 25106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Kundu, E. J. Heilmann, R. Sio, C. Garcia, and R. A. Ostgaard Characterization of an In Vitro Platelet Function Analyzer, PFA-100TM Clinical and Applied Thrombosis/Hemostasis, October 1, 1996; 2(4): 241 - 249. [Abstract] [PDF]
|
|
|
|
|
|
D. D. Hu, C. F. Barbas III, and J. W. Smith An Allosteric Ca2+ Binding Site on the beta3-Integrins That Regulates the Dissociation Rate for RGD Ligands J. Biol. Chem., September 6, 1996; 271(36): 21745 - 21751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mohri, J. Tanabe, K. Katoh, and T. Okubo Identification of a Novel Binding Site to the Integrin alpha IIbbeta 3 Located in the C-terminal Heparin-binding Domain of Human Plasma Fibronectin J. Biol. Chem., June 28, 1996; 271(26): 15724 - 15728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Endenburg, L. Lindeboom-Blokzijl, J. J. Zwaginga, J. J. Sixma, and P. G. de Groot Plasma Fibrinogen Inhibits Platelet Adhesion in Flowing Blood to Immobilized Fibrinogen Arterioscler. Thromb. Vasc. Biol., May 1, 1996; 16(5): 633 - 638. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Loftus, C. E. Halloran, M. H. Ginsberg, L. P. Feigen, J. A. Zablocki, and J. W. Smith The Amino-terminal One-third of alpha[IMAGE] Defines the Ligand Recognition Specificity of Integrin alpha[IMAGE]beta(3) J. Biol. Chem., January 26, 1996; 271(4): 2033 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Savage, E. Bottini, and Z. M. Ruggeri Interaction of Integrin alpha[IMAGE]beta(3) with Multiple Fibrinogen Domains during Platelet Adhesion J. Biol. Chem., December 1, 1995; 270(48): 28812 - 28817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Clements, P Newham, M Shepherd, R Gilbert, T. Dudgeon, L. Needham, R. Edwards, L Berry, A Brass, and M. Humphries Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin J. Cell Sci., January 8, 1994; 107(8): 2127 - 2135. [Abstract] [PDF]
|
|
|
|
 |
|
 M.H. Ginsberg, T.E. O'Toole, J.C. Loftus, and E.F. Plow Ligand Binding to Integrins: Dynamic Regulation and Common Mechanisms Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 221 - 231. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Altieri, O. Etingin, D. Fair, T. Brunck, J. Geltosky, D. Hajjar, and T. Edgington Structurally homologous ligand binding of integrin Mac-1 and viral glycoprotein C receptors Science, November 22, 1991; 254(5035): 1200 - 1202. [Abstract] [PDF]
|
|
|
|
|
|
E Ruoslahti and M. Pierschbacher New perspectives in cell adhesion: RGD and integrins Science, October 23, 1987; 238(4826): 491 - 497. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
