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J. Biol. Chem., Vol. 262, Issue 36, 17432-17436, 12, 1987
K Ueda, I Pastan and MM Gottesman
Intrinsic and acquired multidrug resistance is an important problem in
cancer therapy. Multidrug resistance results from overexpression of the MDR
1 gene, which encodes a drug-efflux pump called P-glycoprotein. We have
isolated a 1-kilobase genomic fragment containing the major transcription
initiation sites for the human MDR 1 gene. Ribonuclease protection
experiments using this fragment indicate that normal human adrenal, colon,
and liver cells, the human hepatoma cell line HepG2, and
vinblastine-selected human KB multidrug-resistant cells initiate
transcription of the MDR 1 gene at the same site within this fragment. The
0.43-kilobase region upstream from the major transcription initiation site
linked to the chloramphenicol acetyltransferase gene showed promoter
activity in CV-1 monkey kidney cells and in human KB cells. The putative
promoter region has a consensus CAAT box and two GC box-like sequences, but
no TATA sequence. This identification and isolation of promoter sequences
for the MDR 1 gene will permit studies on how expression of this gene is
regulated in normal human tissues and cancers.
Isolation and sequence of the promoter region of the human multidrug- resistance (P-glycoprotein) gene
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892.
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|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
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|
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