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J. Biol. Chem., Vol. 263, Issue 16, 7666-7671, 06, 1988
H Werner, Y Koch, F Baldino Jr and I Gozes
The participation of gonadal steroid hormones in the regulation of the
expression of the somatostatin gene in the hypothalamus and cerebral cortex
was studied by using a quantitative densitometric hybridization assay which
allows the direct measurement of specific somatostatin mRNA levels. The
levels of somatostatin mRNA in hypothalamus were found to be significantly
decreased following gonadectomy in both male and female rats (67% in males
and 75% in females). Moreover, with in situ hybridization histochemistry
somatostatin mRNA was similarly reduced following gonadectomy in the dorsal
portion of the periventricular region and in the ventromedial nucleus.
Estradiol dibenzoate treatment reversed the decrease in somatostatin mRNA
in females within 24 h and testosterone treatment reversed the decrease in
castrated males. In contrast, there was no significant change in cerebral
cortex somatostatin mRNA levels after gonadectomy. These results suggest
that sex steroids are involved in the regulation of the somatostatin gene
in the hypothalamus, possibly at the transcriptional level.
Steroid regulation of somatostatin mRNA in the rat hypothalamus
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
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