| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 263, Issue 16, 7741-7746, Jun, 1988
E Van Obberghen-Schilling, NS Roche, KC Flanders, MB Sporn and AB Roberts
Transforming growth factor beta 1 (TGF-beta 1) regulates the growth,
differentiation, or function of nearly all cell types. We now report that
TGF-beta 1 increases steady-state levels of its own message in six
different normal and transformed cells in culture. Accumulation of TGF-
beta 1 mRNA can be detected by Northern blot analysis within 3 h of
addition of the peptide to cells, and enhanced message levels persist as
long as TGF-beta 1 is present in the culture medium. This autoinduction is
half-maximal at approximately 10 PM TGF-beta 1, and maximal stimulation
corresponds to a 2-3-fold increase in transcript levels. In normal rat
kidney cells, the rise in TGF-beta 1 mRNA is actinomycin D-sensitive and is
accompanied by a parallel (approximately 3-fold) increase in secretion of
TGF-beta 1 protein in the culture medium of treated cells, as detected by
immunoprecipitation of biosynthetically labeled 35S-labeled TGF-beta 1
using specific anti-TGF- beta 1 antibodies. Treatment of normal rat kidney
cells with either epidermal growth factor or platelet-derived growth factor
also results in an increase in TGF-beta 1 mRNA (2-3-fold), although
epidermal growth factor and TGF-beta 1 appear to act via distinct
mechanisms since their combined effects are greater than additive.
Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Q. Xiao, C. G. Freire-de-Lima, W. P. Schiemann, D. L. Bratton, R. W. Vandivier, and P. M. Henson Transcriptional and Translational Regulation of TGF-{beta} Production in Response to Apoptotic Cells J. Immunol., September 1, 2008; 181(5): 3575 - 3585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Londesborough, K. Vaahtomeri, M. Tiainen, P. Katajisto, N. Ekman, T. Vallenius, and T. P. Makela LKB1 in endothelial cells is required for angiogenesis and TGF{beta}-mediated vascular smooth muscle cell recruitment Development, July 1, 2008; 135(13): 2331 - 2338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Kelly, Y. Zhang, K. Connelly, A. J. Cox, J. Martin, H. Krum, and R. E. Gilbert Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2860 - H2869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wyatt, C. Wadham, L. A. Crocker, M. Lardelli, and Y. Khew-Goodall The protein tyrosine phosphatase Pez regulates TGF{beta}, epithelial mesenchymal transition, and organ development J. Cell Biol., September 24, 2007; 178(7): 1223 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Pratt, E. C. Schwartz, and T. W. Muir Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt PNAS, July 3, 2007; 104(27): 11209 - 11214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Otsuka, A. Stempien-Otero, A. D. Frutkin, and D. A. Dichek Mechanisms of TGF-{beta}1-Induced Intimal Growth: Plasminogen-Independent Activities of Plasminogen Activator Inhibitor-1 and Heterogeneous Origin of Intimal Cells Circ. Res., May 11, 2007; 100(9): 1300 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Portess, G. Bauer, M. A. Hill, and P. O'Neill Low-Dose Irradiation of Nontransformed Cells Stimulates the Selective Removal of Precancerous Cells via Intercellular Induction of Apoptosis Cancer Res., February 1, 2007; 67(3): 1246 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhang, D. Fraser, and A. Phillips ERK, p38, and Smad Signaling Pathways Differentially Regulate Transforming Growth Factor-{beta}1 Autoinduction in Proximal Tubular Epithelial Cells Am. J. Pathol., October 1, 2006; 169(4): 1282 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Pimanda, W.Y. I. Chan, I. J. Donaldson, M. Bowen, A. R. Green, and B. Gottgens Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer Blood, June 15, 2006; 107(12): 4737 - 4745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stempien-Otero, A. Plawman, J. Meznarich, T. Dyamenahalli, G. Otsuka, and D. A. Dichek Mechanisms of Cardiac Fibrosis Induced by Urokinase Plasminogen Activator J. Biol. Chem., June 2, 2006; 281(22): 15345 - 15351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Mao, E. F. Saunier, J. P. de Koning, M. M. McKinnon, M. N. Higgins, K. Nicklas, H.-T. Yang, A. Balmain, and R. J. Akhurst Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility PNAS, May 23, 2006; 103(21): 8125 - 8130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Meyer-ter-Vehn, S. Gebhardt, W. Sebald, M. Buttmann, F. Grehn, G. Schlunck, and P. Knaus p38 Inhibitors Prevent TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1500 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Otsuka, R. Agah, A. D. Frutkin, T. N. Wight, and D. A. Dichek Transforming Growth Factor Beta 1 Induces Neointima Formation Through Plasminogen Activator Inhibitor-1-Dependent Pathways Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 737 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Song, T. L. Krebs, and D. Danielpour Novel Permissive Role of Epidermal Growth Factor in Transforming Growth Factor beta (TGF-beta) Signaling and Growth Suppression: MEDIATION BY STABILIZATION OF TGF-beta RECEPTOR TYPE II J. Biol. Chem., March 24, 2006; 281(12): 7765 - 7774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Letarte, M.-L. McDonald, C. Li, K. Kathirkamathamby, S. Vera, N. Pece-Barbara, and S. Kumar Reduced endothelial secretion and plasma levels of transforming growth factor-{beta}1 in patients with hereditary hemorrhagic telangiectasia type 1 Cardiovasc Res, October 1, 2005; 68(1): 155 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Valcourt, M. Kowanetz, H. Niimi, C.-H. Heldin, and A. Moustakas TGF-{beta} and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition Mol. Biol. Cell, April 1, 2005; 16(4): 1987 - 2002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. C. Carvalho, L. Jonker, M.-J. Goumans, J. Larsson, P. Bouwman, S. Karlsson, P. t. Dijke, H. M. Arthur, and C. L. Mummery Defective paracrine signalling by TGF{beta} in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia Development, December 15, 2004; 131(24): 6237 - 6247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Suzuki, V. Kapoor, H.-K. Cheung, L. E. Ling, P. A. DeLong, L. R. Kaiser, and S. M. Albelda Soluble Type II Transforming Growth Factor-{beta} Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity Clin. Cancer Res., September 1, 2004; 10(17): 5907 - 5918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ohnishi, T. Miyata, H. Yasuda, Y. Satoh, K. Hanatsuka, H. Kita, A. Ohashi, K. Tamada, N. Makita, T. Iiri, et al. Distinct Roles of Smad2-, Smad3-, and ERK-dependent Pathways in Transforming Growth Factor-{beta}1 Regulation of Pancreatic Stellate Cellular Functions J. Biol. Chem., March 5, 2004; 279(10): 8873 - 8878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Ohnishi, T Miyata, H Ohnishi, H Yasuda, K Tamada, N Ueda, H Mashima, and K Sugano Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis Gut, October 1, 2003; 52(10): 1487 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lamouille, C. Mallet, J.-J. Feige, and S. Bailly Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis Blood, December 15, 2002; 100(13): 4495 - 4501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cheng and J. P. Grande Transforming Growth Factor-{beta} Signal Transduction and Progressive Renal Disease Experimental Biology and Medicine, December 1, 2002; 227(11): 943 - 956. [Abstract] [Full Text]
|
|
|
|
|
|
M. L. Garba, C. D. Pilcher, A. L. Bingham, J. Eron, and J. A. Frelinger HIV Antigens Can Induce TGF-{beta}1-Producing Immunoregulatory CD8+ T Cells J. Immunol., March 1, 2002; 168(5): 2247 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. B. Bastos, J. M. Alvarez, C. R. F. Marinho, L. V. Rizzo, and M. R. D'Imperio Lima Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile J. Leukoc. Biol., February 1, 2002; 71(2): 271 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. C. G. LEE, D. MELKERNEKER, P. J. THOMPSON, R. W. LIGHT, and K. B. LANE Transforming Growth Factor beta Induces Vascular Endothelial Growth Factor Elaboration from Pleural Mesothelial Cells in Vivo and in Vitro Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 88 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Negishi, D. Lu, Y.-Q. Zhang, Y. Sawada, T. Sasaki, T. Kayo, J. Ando, T. Izumi, M. Kurabayashi, I. Kojima, et al. Upregulatory Expression of Furin and Transforming Growth Factor-{beta} by Fluid Shear Stress in Vascular Endothelial Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2001; 21(5): 785 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Dubois, F. Blanchette, M.-H. Laprise, R. Leduc, F. Grondin, and N. G. Seidah Evidence that Furin Is an Authentic Transforming Growth Factor-{beta}1-Converting Enzyme Am. J. Pathol., January 1, 2001; 158(1): 305 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, B. Michelini–Norris, S. Stevens, J. Rowsey, X.-o. Ren, M. Goldstein, and G. Schultz Measurement of mRNAs for TGF{beta} and Extracellular Matrix Proteins in Corneas of Rats after PRK Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4108 - 4116. [Abstract] [Full Text]
|
|
|
|
|
|
E. H. Lee and C.-K. Joo Role of Transforming Growth Factor-{beta} in Transdifferentiation and Fibrosis of Lens Epithelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 1999; 40(9): 2025 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Grewal, Y. V. Mukhin, M. N. Garnovskaya, J. R. Raymond, and E. L. Greene Serotonin 5-HT2A receptor induces TGF-beta 1 expression in mesangial cells via ERK: proliferative and fibrotic signals Am J Physiol Renal Physiol, June 1, 1999; 276(6): F922 - F930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Galdiero, A. Marcatili, G. Cipollaro de l'ero, I. Nuzzo, C. Bentivoglio, M. Galdiero, and C. R. Carratelli Effect of Transforming Growth Factor beta on Experimental Salmonella typhimurium Infection in Mice Infect. Immun., March 1, 1999; 67(3): 1432 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gupta,, N. H. Ing,, F. W. Bazer,, L. S. Bustamante,, and L. A. Jaeger Beta Transforming Growth Factors (TGFß) at the Porcine Conceptus-Maternal Interface. Part I: Expression of TGFß1, TGFß2, and TGFß3 Messenger Ribonucleic Acids Biol Reprod, October 1, 1998; 59(4): 905 - 910. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Seder, T. Marth, M. C. Sieve, W. Strober, J. J. Letterio, A. B. Roberts, and B. Kelsall Factors Involved in the Differentiation of TGF-{beta}-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-{gamma} Have Opposing Effects, While TGF-{beta} Positively Regulates Its Own Production J. Immunol., June 15, 1998; 160(12): 5719 - 5728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Schulick, A. J. Taylor, W. Zuo, C.-b. Qiu, G. Dong, R. N. Woodward, R. Agah, A. B. Roberts, R. Virmani, and D. A. Dichek Overexpression of transforming growth factor beta 1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia PNAS, June 9, 1998; 95(12): 6983 - 6988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lei, S. Silbiger, F. N. Ziyadeh, and J. Neugarten Serum-stimulated alpha 1 type IV collagen gene transcription is mediated by TGF-beta and inhibited by estradiol Am J Physiol Renal Physiol, February 1, 1998; 274(2): F252 - F258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jin and P. H. Howe Regulation of Clusterin Gene Expression by Transforming Growth Factor beta J. Biol. Chem., October 17, 1997; 272(42): 26620 - 26626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, D. E. Solow-Cordero, E. Kessler, K. Takahara, and D. S. Greenspan Transforming Growth Factor-beta Regulation of Bone Morphogenetic Protein-1/Procollagen C-proteinase and Related Proteins in Fibrogenic Cells and Keratinocytes J. Biol. Chem., July 25, 1997; 272(30): 19059 - 19066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Murakami, A. Nifuji, and M. Noda Expression of Indian Hedgehog in Osteoblasts and Its Posttranscriptional Regulation by Transforming Growth Factor-{beta} Endocrinology, May 1, 1997; 138(5): 1972 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nicolini, M. Miloso, M. Moroni, L. Beguinot, and L. Scotto Post-transcriptional Control Regulates Transforming Growth Factor alpha in the Human Carcinoma KB Cell Line J. Biol. Chem., November 22, 1996; 271(47): 30290 - 30296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Iwasaki, T. Homma, Y. Matsuda, and V. Kon Endothelin Receptor Subtype B Mediates Autoinduction of Endothelin-1 in Rat Mesangial Cells J. Biol. Chem., March 24, 1995; 270(12): 6997 - 7003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ribeiro, S Schultz-Cherry, and J. Murphy-Ullrich Heparin-binding vitronectin up-regulates latent TGF-beta production by bovine aortic endothelial cells J. Cell Sci., January 4, 1995; 108(4): 1553 - 1561. [Abstract] [PDF]
|
|
|
|
|
|
D. Hursh, R. Padgett, and W. Gelbart Cross regulation of decapentaplegic and Ultrabithorax transcription in the embryonic visceral mesoderm of Drosophila Development, January 4, 1993; 117(4): 1211 - 1222. [Abstract] [PDF]
|
|
|
|
|
|
T Ziv, Y Shimoni, and E Mitrani Activin can generate ectopic axial structures in chick blastoderm explants Development, January 7, 1992; 115(3): 689 - 694. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Chipuk, S. C. Cornelius, N. J. Pultz, J. S. Jorgensen, M. J. Bonham, S.-J. Kim, and D. Danielpour The Androgen Receptor Represses Transforming Growth Factor-beta Signaling through Interaction with Smad3 J. Biol. Chem., January 4, 2002; 277(2): 1240 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suthanthiran, B. Li, J. O. Song, R. Ding, V. K. Sharma, J. E. Schwartz, and P. August Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage PNAS, March 28, 2000; 97(7): 3479 - 3484. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
