| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 263, Issue 21, 10240-10246, 07, 1988
A Oohira, F Matsui, M Matsuda, Y Takida and Y Kuboki
More than 60% of brain chondroitin sulfate proteoglycans were extracted
from 10-day-old rat brains by homogenization in ice-cold phosphate-
buffered saline containing protease inhibitors. Although the soluble
proteoglycan preparation was a mixture of chondroitin sulfate proteoglycans
with a different hydrodynamic size as well as a different molecular
density, each subfraction of the proteoglycans contained chondroitin
sulfate side chains with virtually identical molecular weight
(approximately 15,000) and chondroitin sulfate disaccharide composition
(high content of 4-sulfate unit). Digestion of the purified proteoglycan
preparation with protease-free chondroitinase ABC produced five core
proteins with Mr = 250,000 (designated as 250K protein), 220,000 (220K),
150,000 (150K), 130,000 (130K), and 93,000 (93K). All these core proteins
were obtained from chondroitin sulfate proteoglycan preparations extracted
from various regions of the brain, but their composition varied among
different brain regions. Analysis for amino acid composition of these core
proteins and two-dimensional mapping of their proteolytic peptides revealed
that three major core proteins (250K, 220K, and 150K proteins) were
structurally different. These observations indicate that at least three
distinct types of chondroitin sulfate proteoglycan occur in the developing
rat brain.
Occurrence of three distinct molecular species of chondroitin sulfate proteoglycan in the developing rat brain
Department of Embryology, Institute for Developmental Research, Aichi, Japan.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Akita, A. von Holst, Y. Furukawa, T. Mikami, K. Sugahara, and A. Faissner Expression of Multiple Chondroitin/Dermatan Sulfotransferases in the Neurogenic Regions of the Embryonic and Adult Central Nervous System Implies That Complex Chondroitin Sulfates Have a Role in Neural Stem Cell Maintenance Stem Cells, March 1, 2008; 26(3): 798 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aono, Y. Tokita, T. Shuo, S. Yamauchi, F. Matsui, K. Nakanishi, K. Hirano, M. Sano, and A. Oohira Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C J. Biol. Chem., November 5, 2004; 279(45): 46536 - 46541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Bao, S. Nishimura, T. Mikami, S. Yamada, N. Itoh, and K. Sugahara Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Embryonic Pig Brain, Which Contain a Higher Proportion of L-Iduronic Acid than Those from Adult Pig Brain, Exhibit Neuritogenic and Growth Factor Binding Activities J. Biol. Chem., March 12, 2004; 279(11): 9765 - 9776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Inatani, M. Honjo, Y. Otori, A. Oohira, N. Kido, Y. Tano, Y. Honda, and H. Tanihara Inhibitory Effects of Neurocan and Phosphacan on Neurite Outgrowth from Retinal Ganglion Cells in Culture Invest. Ophthalmol. Vis. Sci., July 1, 2001; 42(8): 1930 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inatani, H. Tanihara, A. Oohira, Y. Otori, A. Nishida, M. Honjo, N. Kido, and Y. Honda Neuroglycan C, a Neural Tissue-Specific Transmembrane Chondroitin Sulfate Proteoglycan, in Retinal Neural Network Formation Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4338 - 4346. [Abstract] [Full Text]
|
|
|
|
|
|
M. Inatani, H. Tanihara, A. Oohira, M. Honjo, N. Kido, and Y. Honda Spatiotemporal Expression Patterns of 6B4 Proteoglycan/Phosphacan in the Developing Rat Retina Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1990 - 1997. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Immergluck, M. Domowicz, N. Schwartz, and B. Herold Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells J. Gen. Virol., March 1, 1998; 79(3): 549 - 559. [Abstract]
|
|
|
|
 |
|
 R Tuttle, J. Braisted, L. Richards, and D. O'Leary Retinal axon guidance by region-specific cues in diencephalon Development, January 3, 1998; 125(5): 791 - 801. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Lander, H. Zhang, and S. Hockfield Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan J. Neurosci., January 1, 1998; 18(1): 174 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kitagawa, K. Tsutsumi, Y. Tone, and K. Sugahara Developmental Regulation of the Sulfation Profile of Chondroitin Sulfate Chains in the Chicken Embryo Brain J. Biol. Chem., December 12, 1997; 272(50): 31377 - 31381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lander, P. Kind, M. Maleski, and S. Hockfield A Family of Activity-Dependent Neuronal Cell-Surface Chondroitin Sulfate Proteoglycans in Cat Visual Cortex J. Neurosci., March 15, 1997; 17(6): 1928 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Maeda and M Noda 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons Development, January 2, 1996; 122(2): 647 - 658. [Abstract] [PDF]
|
|
|
|
|
|
E. Watanabe, N. Maeda, F. Matsui, Y. Kushima, M. Noda, and A. Oohira Neuroglycan C, a Novel Membrane-spanning Chondroitin Sulfate Proteoglycan That Is Restricted to the Brain J. Biol. Chem., November 10, 1995; 270(45): 26876 - 26882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Fernaud-Espinosa, M Nieto-Sampedro, and P Bovolenta Differential effects of glycosaminoglycans on neurite outgrowth from hippocampal and thalamic neurones J. Cell Sci., January 6, 1994; 107(6): 1437 - 1448. [Abstract] [PDF]
|
|
|
|
|
|
L. Smith-Thomas, J Fok-Seang, J Stevens, J. Du, E Muir, A Faissner, H. Geller, J. Rogers, and J. Fawcett An inhibitor of neurite outgrowth produced by astrocytes J. Cell Sci., January 6, 1994; 107(6): 1687 - 1695. [Abstract] [PDF]
|
|
|
|
|
|
C. Ueoka, N. Kaneda, I. Okazaki, S. Nadanaka, T. Muramatsu, and K. Sugahara Neuronal Cell Adhesion, Mediated by the Heparin-binding Neuroregulatory Factor Midkine, Is Specifically Inhibited by Chondroitin Sulfate E. STRUCTURAL AND FUNCTIONAL IMPLICATIONS OF THE OVER-SULFATED CHONDROITIN SULFATE J. Biol. Chem., November 22, 2000; 275(48): 37407 - 37413. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
