| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 263, Issue 23, 11063-11066, Aug, 1988
GM Janssen, GD Maessen, R Amons and W Moller
Elongation factor 1 beta (EF-1 beta) from Artemia is phosphorylated to a
high percentage at serine 89 by an endogenous kinase present in EF-1 beta
gamma. Protein sequencing of EF-1 beta revealed that this serine residue is
located N-terminally of an acidic cluster of amino acids, (formula; see
text) which is critical for casein kinase II-type substrate recognition. A
number of compounds known to influence casein kinases were studied,
revealing that the kinase activity as present in EF-1 beta gamma belongs to
the class of casein kinase II. The rate of nucleotide exchange on EF-1
alpha as catalyzed by EF-1 beta was found to be affected reversibly by the
state of phosphorylation of EF-1 beta. In the presence of dephosphorylated
EF-1 beta, the exchange rate is almost twice as large compared to the rate
in the presence of phosphorylated EF-1 beta. Rephosphorylation of
dephosphorylated EF-1 beta diminishes the activity of the protein again.
The role of casein kinase II-type enzymes in modulating the function of
proteins involved in polypeptide synthesis is discussed.
Phosphorylation of elongation factor 1 beta by an endogenous kinase affects its catalytic nucleotide exchange activity
Laboratory for Physiological Chemistry, Sylvius Laboratories, Leiden, The Netherlands.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. B. Ozturk, M. R. Vishnu, O. Olarewaju, L. M. Starita, D. C. Masison, and T. G. Kinzy Unique Classes of Mutations in the Saccharomyces cerevisiae G-Protein Translation Elongation Factor 1A Suppress the Requirement for Guanine Nucleotide Exchange Genetics, October 1, 2006; 174(2): 651 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-L. Ong, C. P. N. Er, A. Ho, M. T. Aung, and H. Yu Kinectin Anchors the Translation Elongation Factor-1{delta} to the Endoplasmic Reticulum J. Biol. Chem., August 22, 2003; 278(34): 32115 - 32123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Carr-Schmid, L. Valente, V. I. Loik, T. Williams, L. M. Starita, and T. G. Kinzy Mutations in Elongation Factor 1beta , a Guanine Nucleotide Exchange Factor, Enhance Translational Fidelity Mol. Cell. Biol., August 1, 1999; 19(8): 5257 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Negrutskii, V. F. Shalak, P. Kerjan, A. V. El'skaya, and M. Mirande Functional Interaction of Mammalian Valyl-tRNA Synthetase with Elongation Factor EF-1alpha in the Complex with EF-1H J. Biol. Chem., February 19, 1999; 274(8): 4545 - 4550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-T. Sheu and J. A. Traugh Recombinant Subunits of Mammalian Elongation Factor 1 Expressed in Escherichia coli. SUBUNIT INTERACTIONS, ELONGATION ACTIVITY, AND PHOSPHORYLATION BY PROTEIN KINASE CKII J. Biol. Chem., December 26, 1997; 272(52): 33290 - 33297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. E. Chang and J. A. Traugh Phosphorylation of Elongation Factor 1 and Ribosomal Protein S6 by Multipotential S6 Kinase and Insulin Stimulation of Translational Elongation J. Biol. Chem., November 7, 1997; 272(45): 28252 - 28257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. de Nadal, R. P. Fadden, A. Ruiz, T. Haystead, and J. Arino A Role for the Ppz Ser/Thr Protein Phosphatases in the Regulation of Translation Elongation Factor 1Balpha J. Biol. Chem., April 27, 2001; 276(18): 14829 - 14834. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
