JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Finkelstein, J. D.
Right arrow Articles by Harris, B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Finkelstein, J. D.
Right arrow Articles by Harris, B. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J. Biol. Chem., Vol. 263, Issue 24, 11750-11754, 08, 1988

Methionine metabolism in mammals. The methionine-sparing effect of cystine

JD Finkelstein, JJ Martin and BJ Harris
Veterans Administration Medical Center, Washington, D.C. 20422.

Cystine can replace approximately 70% of the dietary requirement for methionine. We used standard enzyme assays, determinations of the hepatic concentrations of metabolites and an in vitro system which simulates the regulatory site formed by the enzymes which utilize homocysteine in this study of the mechanism for this adaptation. A significant alteration in the pattern of hepatic homocysteine metabolism occurs following the substitution of cystine for methionine. The major change is a marked reduction in the synthesis of cystathionine. Decreases in both the level of cystathionine synthase and in the concentration of adenosyl-methionine, a positive effector of the enzyme, explain this finding. Despite significant increases in the hepatic levels of betaine-homocysteine methyltransferase and methyltetrahydrofolate-homocysteine methyltransferase, flow through these reactions remains relatively constant. The betaine enzyme may be essential for efficient methionine conservation. In the absence of choline, cystine cannot replace methionine in an adequate diet limited in the latter amino acid.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
G. E. Luzardo, R. A. Karlnoski, B. Williams, D. Mangar, and E. M. Camporesi
Anesthetic Management of a Parturient with Hyperhomocysteinemia
Anesth. Analg., June 1, 2008; 106(6): 1833 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
R. N. Dilger and D. H. Baker
DL-Methionine Is as Efficacious as L-Methionine, but Modest L-Cystine Excesses Are Anorexigenic in Sulfur Amino Acid-Deficient Purified and Practical-Type Diets Fed to Chicks
Poult. Sci., November 1, 2007; 86(11): 2367 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. O. Uthus, P. G. Reeves, and J. T. Saari
Copper Deficiency Decreases Plasma Homocysteine in Rats
J. Nutr., June 1, 2007; 137(6): 1370 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. I. Holm, S. Hustad, P. M. Ueland, S. E. Vollset, T. Grotmol, and J. Schneede
Modulation of the Homocysteine-Betaine Relationship by Methylenetetrahydrofolate Reductase 677 C->T Genotypes and B-Vitamin Status in a Large-Scale Epidemiological Study
J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1535 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
P. B. Pillai, A. C. Fanatico, M. E. Blair, and J. L. Emmert
Homocysteine remethylation in broilers fed surfeit choline or betaine and varying levels and sources of methionine from eight to twenty-two days of age.
Poult. Sci., October 1, 2006; 85(10): 1729 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. H. Baker
Comparative Species Utilization and Toxicity of Sulfur Amino Acids
J. Nutr., June 1, 2006; 136(6): 1670S - 1675S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. O. Ball, G. Courtney-Martin, and P. B. Pencharz
The In Vivo Sparing of Methionine by Cysteine in Sulfur Amino Acid Requirements in Animal Models and Adult Humans
J. Nutr., June 1, 2006; 136(6): 1682S - 1693S.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Toue, R. Kodama, M. Amao, Y. Kawamata, T. Kimura, and R. Sakai
Screening of Toxicity Biomarkers for Methionine Excess in Rats
J. Nutr., June 1, 2006; 136(6): 1716S - 1721S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
N. Fillon-Emery, A. Chango, C. Mircher, F. Barbe, H. Blehaut, B. Herbeth, D. S Rosenblatt, M.-O. Rethore, D. Lambert, and J. P. Nicolas
Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms
Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1551 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
P. Verhoef, G. R Steenge, E. Boelsma, T. van Vliet, M. R Olthof, and M. B Katan
Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans
Am. J. Clinical Nutrition, September 1, 2004; 80(3): 674 - 679.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. Di Buono, L. J. Wykes, D. E. C. Cole, R. O. Ball, and P. B. Pencharz
Regulation of Sulfur Amino Acid Metabolism in Men in Response to Changes in Sulfur Amino Acid Intakes
J. Nutr., March 1, 2003; 133(3): 733 - 739.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. Bottiglieri
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule
Am. J. Clinical Nutrition, November 1, 2002; 76 (5): 1151S - 1157S.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
C. A. Loest, E. C. Titgemeyer, G. S.-J. D. C. Van Metre, and J. S. Smith
Methionine as a methyl group donor in growing cattle
J Anim Sci, August 1, 2002; 80(8): 2197 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
B. D. Lambert, E. C. Titgemeyer, G. L. Stokka, B. M. DeBey, and C. A. Loest
Methionine Supply to Growing Steers Affects Hepatic Activities of Methionine Synthase and Betaine-Homocysteine Methyltransferase, but Not Cystathionine Synthase
J. Nutr., July 1, 2002; 132(7): 2004 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. R Young
Got some amino acids to spare?
Am. J. Clinical Nutrition, December 1, 2001; 74(6): 709 - 711.
[Full Text]

Home page
 Am. J. Clin. Nutr.Home page
M. Di Buono, L. J Wykes, R. O Ball, and P. B Pencharz
Dietary cysteine reduces the methionine requirement in men
Am. J. Clinical Nutrition, December 1, 2001; 74(6): 761 - 766.
[Abstract] [Full Text]

Home page
 Crop Sci.Home page
J. Imsande
Selection of Soybean Mutants with Increased Concentrations of Seed Methionine and Cysteine
Crop Sci., March 1, 2001; 41(2): 510 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J.-C. Minet, E. Bisse, C.-P. Aebischer, A. Beil, H. Wieland, and J. Lutschg
Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates
Am. J. Clinical Nutrition, September 1, 2000; 72(3): 751 - 757.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
G. N. Welch and J. Loscalzo
Homocysteine and Atherothrombosis
N. Engl. J. Med., April 9, 1998; 338(15): 1042 - 1050.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1988 by the American Society for Biochemistry and Molecular Biology.