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J. Biol. Chem., Vol. 263, Issue 25, 12167-12170, 09, 1988
R Nichols, SA Schneuwly and JE Dixon
Homologues to the cholecystokinin (CCK)-gastrin peptide family have been
cloned from Drosophila. The CCK-like precursor found in Drosophila has been
designated drosulfakinin (DSK). Genomic and cDNA clones corresponding to
the Drosophila neuropeptide precursor encode for three putative peptides.
The three peptides (DSK-0, Asn-Gln-Lys-Thr-Met-Ser- Phe-Gly; DSK-I,
Phe-Asp-Asp-Tyr-Gly-His-Met-Arg-Phe-Gly; DSK-II, Gly-
Gly-Asp-Asp-Gln-Phe-Asp-Asp-Tyr-Gly-His-Met-Arg-Phe-Gly) are flanked by
prohormone processing sites and contain C-terminal glycyl residues, a
potential amidation site. Two of the peptides, DSK-I and DSK-II, are
homologous to CCK-gastrin peptides. Each of the two homologues include a
CCK-gastrin-like C-terminal pentapeptide and a conserved sequence
corresponding to the sulfated tyrosine in bioactive CCK. The third peptide
encoded by the drosulfakinin precursor represents a novel peptide. In situ
tissue hybridization indicates the presence of the transcript in the adult
head. Chromosomal localization maps the gene to the third chromosome near
81F.
Identification and characterization of a Drosophila homologue to the vertebrate neuropeptide cholecystokinin
Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907.
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