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J. Biol. Chem., Vol. 263, Issue 26, 12828-12831, Sep, 1988

Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures

TI Morales and AB Roberts
Bone Research Branch, National Institute of Dental Research, Bethesda, Maryland 20892.

The effect of transforming growth factor beta (TGF-beta) has been studied in a bovine articular cartilage organ culture. The peptide stimulates synthesis of proteoglycans in a dose-dependent manner, reaching saturation at 10 ng/ml. This dose gave an approximate 7-fold increase in synthesis over basal controls. In addition, the peptide decreased the rates of catabolism of proteoglycans with an approximately 2-fold maximal effect seen at 5 ng/ml. At the latter concentration, TGF-beta prevented the 4-fold loss of proteoglycans which occurred in cultures maintained under basal conditions over the course of 3 weeks. There was no increase in cell (DNA) content of the cartilage explants under these conditions of TGF-beta treatment, and the net collagen content of the explants remained constant.
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